PMID: 7543028Jan 1, 1995Paper

Taxol encapsulation in poly(epsilon-caprolactone) microspheres

Cancer Chemotherapy and Pharmacology
S K DordunooH M Burt

Abstract

Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.

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Citations

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