PMID: 8581880Dec 1, 1995Paper

Taxol inhibits osteoclastic bone resorption

Calcified Tissue International
T J HallM Schaueblin

Abstract

We have examined the effect of the anti-tumor compound taxol, on osteoclastic bone resorption. In the bone slice assay, taxol (0.1-0.001 microM) dose-dependently inhibited bone resorption with an IC50 of 0.08 microM. Osteoclast survival on bone slices was unaffected by 0.01-1 microM taxol, but 10 microM was cytotoxic. Taxol (1 microM) also inhibited osteoclast spreading (45%) on fibronectin-coated slides. The antiproliferative effects of taxol are due to its unique ability to stabilize microtubules. Primary osteoclasts are nonproliferating end cells, so taxol probably inhibits bone resorption by interfering with other microtubule-dependent functions such as cell polarization, motility or vesicle exocytosis. Since these inhibitory effects on osteoclasts in vitro are seen with therapeutically relevant concentrations, taxol therapy may have beneficial side-effects e.g. inhibition of hypercalcemia and bone metastases.

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Citations

Nov 26, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A StrubeS-M Käkönen
Dec 17, 2008·Journal of Bone and Mineral Metabolism·Masahiro TakahashiNaoyuki Takahashi
Oct 9, 2015·Yonsei Medical Journal·Yoon Sok ChungTaeyong Lee
Jan 1, 1997·Cell Motility and the Cytoskeleton·S G BabbS S Lim
Oct 20, 2020·Current Osteoporosis Reports·Cari M WhyneMichael Hardisty
May 28, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne StrubeSanna-Maria Käkönen

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