PMID: 9557161Apr 29, 1998Paper

Taxol involution of collagen-induced arthritis: ultrastructural correlation with the inhibition of synovitis and neovascularization

Clinical Immunology and Immunopathology
A L ArsenaultE Brahn

Abstract

Collagen-induced arthritis (CIA) is an animal model of rheumatoid arthritis (RA) that can be regressed with Taxol (paclitaxel), a chemotherapeutic agent. To identify structural changes that occur with involution, the synovium from naive, untreated CIA, and Taxol-treated CIA rats were evaluated by light microscopy plus transmission and scanning electron microscopy. Analysis included detailed images of vascular networks using polymeric corrosion casts. The CIA synovium was morphologically similar to human RA synovium. In CIA, the integrity of the intimal lining is lost by Type-B synoviocytes becoming highly elongated and polarized toward the joint space, resulting in non-overlapping cellular processes and the elimination of the basal lamina. In addition, the lining expanded from a width of 6-10 microns in naives to 200-250 microns in CIA due primarily to increased numbers of both Type-A and -B synoviocytes and more interstitial matrix. Vascular corrosion casts of CIA synovium illustrated a marked increase in blood vessel volume and an extensive interconnecting vascular architecture; neovascular arrays were observed to project toward the synovial surface. In Taxol-treated CIA, the synoviocyte and neovascular components reverted to...Continue Reading

References

Sep 1, 1977·The Journal of Experimental Medicine·D E TrenthamA H Kang
Apr 1, 1992·Trends in Pharmacological Sciences·S B Horwitz
Jul 1, 1992·Annals of the Rheumatic Diseases·P R Colville-Nash, D L Scott
Jan 1, 1990·Rheumatology International·L E PollockP A Revell
Jan 1, 1990·Rheumatology International·C R StevensP A Revell
Jan 1, 1967·Annals of the Rheumatic Diseases·S Roy, F N Ghadially
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·A DryllA Ryckewaert
Feb 1, 1995·Cellular Immunology·D J PeacockE Brahn
May 1, 1995·Annals of the Rheumatic Diseases·N A Athanasou
May 1, 1995·Annals of the Rheumatic Diseases·J C Edwards
May 1, 1995·Annals of the Rheumatic Diseases·P A RevellD Osei
Jun 1, 1994·Arthritis and Rheumatism·E BrahnM L Banquerigo
Aug 1, 1962·The Journal of Cell Biology·P BARLANDD HAMERMAN

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Citations

Sep 7, 2002·Archives of Pharmacal Research·Yun Seon SongChangbae Jin
Apr 26, 2007·Angiogenesis·Carla CostaRaquel Soares
Mar 23, 2004·Journal of the American Academy of Dermatology·Alison EhrlichAndrew Blauvelt
Jan 7, 2004·Journal of the Neurological Sciences·Shauna KirkStephen Karlik
Oct 29, 2000·Annals of the Rheumatic Diseases·A E Koch
Oct 9, 2003·Annals of the Rheumatic Diseases·A E Koch
Jan 12, 1999·The Journal of Clinical Investigation·G S Firestein
Mar 21, 2002·The Lancet Oncology·G Gasparini
Jan 28, 2014·Plant Cell Reports·Md Mohidul HasanKwang-Hyun Baek
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·T M HaqqiH Mukhtar
Feb 16, 2005·Expert Opinion on Investigational Drugs·Dahlia T Lainer, Ernest Brahn
Feb 16, 2005·Expert Opinion on Investigational Drugs·K F Chung
Feb 20, 2016·European Journal of Oral Sciences·Maha M Mahmoud, Marwa M Afifi
Sep 8, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Aqeel JaveedMuhammad Mahmood Mukhtar
Mar 1, 2007·Environmental Toxicology and Pharmacology·Suk-Jong SuhCheorl-Ho Kim
Jun 9, 2001·Rheumatic Diseases Clinics of North America·L W Moreland
Jul 17, 2001·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·B BragdonS E Weisbrode
Mar 23, 2017·Asian Cardiovascular & Thoracic Annals·Feridoun Sabzi, Reza Faraji
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michel De BandtCatherine Pasquier
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K D MillerG W Sledge

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