PMID: 9542904May 23, 1998Paper

Taxonomic relationships among spotted fever group rickettsiae as revealed by antigenic analysis with monoclonal antibodies

Journal of Clinical Microbiology
W Xu, D Raoult

Abstract

The spotted fever group (SFG) is made up of more than 20 different rickettsial species and strains. Study of the taxonomic relationships among the group has been attempted by phenotypic, genotypic, and phylogenetic analyses. In this study, we determined taxonomic relationships among the SFG rickettsiae by comparative analysis of immunogenic epitopes reactive against a panel of monoclonal antibodies. A total of 98 monoclonal antibodies, which were directed against epitopes on the major immunodominant proteins or on the lipopolysaccharide-like antigens of strains of Rickettsia africae, Rickettsia conorii, Rickettsia massiliae, Rickettsia akari, Rickettsia sibirica, and Rickettsia slovaca, were used in the study. The distribution and expression of the epitopes among 29 SFG rickettsiae and Rickettsia bellii were assessed by determination of reaction titers in a microimmunofluorescence assay. The results were scored as numerical taxonomic data, and cluster analysis was used to construct a dendrogram. The architecture of this dendrogram was consistent with previous taxonomic studies, and the implications of this and other findings are discussed.

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Citations

Mar 11, 2003·Clinical and Diagnostic Laboratory Immunology·Rong Fang, Didier Raoult
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Hisashi InokumaDidier Raoult
Nov 9, 2000·The British Journal of Dermatology·O RouxJ P Ortonne
Jun 23, 2009·Annals of the New York Academy of Sciences·Pierre-Edouard Fournier, Didier Raoult
Jun 10, 2006·Annals of Tropical Medicine and Parasitology·L LledóF Bacellar
Jul 1, 2010·Emerging Infectious Diseases·Allen L RichardsM Kariuki Njenga
Jan 15, 2020·International Journal of Systematic and Evolutionary Microbiology·Awa DiopPierre-Edouard Fournier
Jul 16, 2003·Annals of the New York Academy of Sciences·R FangD Raoult

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