PMID: 8601727Feb 1, 1996Paper

Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin

The Journal of Investigative Dermatology
S NagpalR A Chandraratna

Abstract

Retinoids exert their effect through ligand-dependent transcription factors, retinoic acid receptors (RARalpha, beta, and gamma) and retinoid X receptor (RXRalpha, beta, and gamma), which belong to the superfamily of steroid/thyroid/vitamin D3, nuclear receptors. Using a subtraction hybridization approach, we have identified a cDNA sequence, Tazarotene Induced Gene 1 (TIG1), which is highly upregulated in skin raft cultures by an RARbeta/gamma -selective retinoid AGN 190168 (tazarotene/ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)-ethynyl]nicotinate), which is effective in the treatment of psoriasis. The retinoid-mediated upregulation in the expression of TIG1 was confirmed by Southern and Northern analyses. Upon sequencing, TIG1 was found to be a novel cDNA which encodes a protein of 228 amino acids whose sequence suggests that is a transmembrane protein with a small N-terminal intracellular region, a single membrane-spanning hydrophobic region, and a large C-terminal extracellular region containing a glycosylation signal. We demonstrate that TIG1 is also upregulated by AGN 190168 in skin raft cultures prepared from psoriatic fibroblasts and normal keratinocytes and in primary fibroblast and keratinocyte cultures. We also show tha...Continue Reading

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Citations

Mar 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Irantzu PallarèsF Xavier Gomis-Rüth
May 14, 2011·Journal of Cellular Physiology·Kanae MitsunagaYusuke Furukawa
Mar 24, 2000·The British Journal of Dermatology·H Gollnick, A Menter
Oct 1, 1996·The British Journal of Dermatology·R A Chandraratna
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·S Nagpal, R A Chandraratna
Aug 3, 2005·American Journal of Clinical Dermatology·Toni M Dando, Keri Wellington
Dec 17, 2017·Reproductive Sciences·Hanna HuebnerMatthias Ruebner
Apr 21, 2020·British Journal of Cancer·Lehel PeterfiGyula Kovacs
Nov 4, 2000·Expert Opinion on Investigational Drugs·D DiSepio, R A Chandraratna
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Joseph KwongDolly P Huang
Mar 5, 2008·The Journal of Clinical Investigation·Amanda M NelsonDiane M Thiboutot
Jun 12, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Catherine ItmanKate L Loveland
Sep 4, 2012·International Journal of Molecular Sciences·Hui-Ling ChenYetrib Hathout
Jul 8, 2020·The Journal of Clinical Investigation·Anqun ChenJohn Cijiang He
Sep 23, 2008·Genes, Chromosomes & Cancer·Vanessa F BonazziNicholas K Hayward
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·D DiSepioS Nagpal
Sep 14, 2012·Pediatric Dermatology·Cairine WilkinsonVandana Ramrakha-Jones
Sep 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xi-Hua ChenJian Ding
Jun 7, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Andreas TeufelFrank Lammert
Nov 25, 2017·Journal of Experimental & Clinical Cancer Research : CR·H HuebnerF B Fahlbusch
Jan 8, 2020·International Journal of Molecular Sciences·Alexander MockerFabian B Fahlbusch
May 7, 2020·Food & Function·Noelia Morales-PrietoNieves Abril
Dec 3, 1999·The British Journal of Dermatology·B HofmannP Lehmann
Mar 2, 2021·American Journal of Physiology. Renal Physiology·Anqun ChenJohn Cijiang He

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