Tazobactam-piperacillin compared with sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam-cefoperazone, and piperacillin for activity against beta-lactamase-producing bacteria isolated from patients with complicated urinary tract infections

Journal of Chemotherapy
S NomuraA Nagayama

Abstract

The antibacterial activity of tazobactam-piperacillin was compared with that of sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam-cefoperazone and piperacillin against beta-lactamase-producing bacteria isolated from patients with complicated urinary tract infections. Tazobactam-piperacillin showed a broad antibacterial spectrum against gram-negative and gram-positive bacteria. The minimum inhibitory concentrations (MIC90) of tazobactam-piperacillin were 6.25 micrograms/ml against Escherichia coli, 1.56 micrograms/ml against Proteus mirabilis, 3.13 micrograms/ml against Proteus vulgaris, 6.25 micrograms/ml against methicillin-susceptible Staphylococcus aureus, and 6.25 micrograms/ml coagulase-negative methicillin-susceptible staphylococci. Against all beta-lactamase-producing bacteria tested the antibacterial activity of tazobactam-piperacillin was at least 4- to 64-fold stronger than that of piperacillin, clavulanic acid-ticarcillin, and sulbactam-ampicillin, and similar to or greater than that of sulbactam-cefoperazone except for E. coli.

References

Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W E Sanders, C C Sanders

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Citations

Dec 20, 2008·International Journal of Pediatric Otorhinolaryngology·Chul Ho JangIl Yong Park
Oct 11, 2008·International Journal of Pediatric Otorhinolaryngology·Chul-Ho JangCheol-Hee Choi
Oct 22, 2020·Research : a Science Partner Journal·Zifang ShangWei Huang
Dec 17, 2020·Frontiers in Microbiology·Aneta FilipiakWioletta Adamus-Białek

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