TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability.

Cancer Discovery
Ziad Bakouny, David A Barbie

Abstract

The Von Hippel-Lindau gene product is a tumor suppressor whose ubiquitin ligase function is key to oxygen-sensing in cells, whereas Tank-binding kinase (TBK1) is a kinase mostly implicated in innate immune response. The study by Hu and colleagues in this issue reveals that VHL suppresses TBK1 activity under normoxic conditions, and that loss of VHL in kidney cancer cells renders them sensitive to TBK1 inhibition, providing a new potential target for the treatment of clear cell renal cell carcinoma.See related article by Hu et al., p. 460.

References

Dec 24, 2014·Nature Reviews. Cancer·Lucy GossageEamonn R Maher
Nov 5, 2017·Cancer Discovery·Russell W JenkinsDavid A Barbie
Dec 20, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin D CourtneyToni K Choueiri
Jul 25, 2018·Nature Medicine·Israel CañadasDavid Allen Barbie
Sep 19, 2018·Cells·Joel K DurandAlbert S Baldwin
Oct 30, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rana R McKayToni K Choueiri
Dec 8, 2019·Cancer Discovery·Lianxin HuQing Zhang
Dec 20, 2019·Cancer Discovery·John Kwon, Samuel F Bakhoum

❮ Previous
Next ❯

Citations

Sep 24, 2020·Expert Opinion on Therapeutic Targets·Or-Yam RevachRussell W Jenkins
Oct 7, 2020·Nature Medicine·Toni K Choueiri, William G Kaelin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.