Tbx1 is necessary for palatal elongation and elevation

Mechanisms of Development
Steven GoudyChristopher B Brown


The transcription factor TBX1 is a key mediator of developmental abnormalities associated with DiGeorge/Velocardiofacial Syndrome. Studies in mice have demonstrated that decreased dosage of Tbx1 results in defects in pharyngeal arch, cardiovascular, and craniofacial development. The role of Tbx1 in cardiac development has been intensely studied; however, its role in palatal development is poorly understood. By studying the Tbx1-/- mice we found defects during the critical points of palate elongation and elevation. The intrinsic palate defects in the Tbx1-/- mice were determined by measuring changes in palate shelf length, proliferation, apoptosis, expression of relevant growth factors, and in palate fusion assays. Tbx1-/- embryos exhibit cleft palate with failed palate elevation in 100% and abnormal palatal-oral fusions in 50%. In the Tbx1-/- mice the palate shelf length was reduced and tongue height was greater, demonstrating a physical impediment to palate elevation and apposition. In vitro palate fusion assays demonstrate that Tbx1-/- palate shelves are capable of fusion but a roller culture assay showed that the null palatal shelves were unable to elongate. Diminished hyaluronic acid production in the Tbx1-/- palate shelves...Continue Reading


Sep 3, 2013·Current Allergy and Asthma Reports·Shan GaoBrad A Amendt
Mar 1, 2012·Human Molecular Genetics·Noriko FunatoHiromi Yanagisawa
Sep 25, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·Sivakumar Chinnadurai, Steven Goudy
Feb 23, 2011·Development, Growth & Differentiation·Sachiko Iseki
Mar 26, 2013·Medicina oral, patología oral y cirugía bucal·Lívia-Máris-Ribeiro ParanaíbaMário-Sérgio-Oliveira Swerts
Dec 20, 2014·Developmental Biology·Jamie LaneVesa Kaartinen
Sep 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Junko OkanoYasuo Sakai
May 17, 2011·American Journal of Medical Genetics. Part a·Nicholas K RorickBrian C Schutte
Nov 11, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cynthia HillSteven L Goudy
Apr 14, 2015·Progress in Neurobiology·Daniel W MeechanAnthony-S LaMantia
Feb 14, 2015·Biochemical and Biophysical Research Communications·Shiying LiuKeiji Moriyama
Jan 11, 2019·International Journal of Oncology·Yilong HaoQianming Chen
Dec 26, 2018·Journal of Dental Research·R LiZ Chen
Mar 5, 2019·Laryngoscope Investigative Otolaryngology·Anita S Deshpande, Steven L Goudy
Apr 20, 2017·Frontiers in Physiology·Christian SchoenCarine E L Carels


Aug 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D L ChapmanV E Papaioannou
May 9, 1998·Genes & Development·Rulang JiangT Gridley
Dec 2, 2004·Developmental Biology·Sylvia R AlappatYiPing Chen
Oct 29, 2005·Brain, Behavior and Evolution·Paul A Trainor
Feb 3, 2006·Development·Jelena S ArnoldBernice E Morrow
Apr 6, 2006·The International Journal of Developmental Biology·Maria ZoupaMartyn T Cobourne
May 9, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yang Chai, Robert E Maxson
Sep 1, 2006·Developmental Biology·Amel Gritli-Linde
Sep 27, 2006·Human Molecular Genetics·Vimla S AggarwalBernice E Morrow
Oct 17, 2006·Nature Genetics·Rebecca J RichardsonMichael J Dixon
Jul 17, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ali Nawshad
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Xi HuangChin Chiang
May 15, 2009·Human Molecular Genetics·Rebecca J RichardsonMichael J Dixon

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