Tbx1 regulates inherited metabolic and myogenic abilities of progenitor cells derived from slow- and fast-type muscle

Cell Death and Differentiation
Norio MotohashiKazuhiro Shigemoto

Abstract

Skeletal muscle is divided into slow- and fast-type muscles, which possess distinct contractile and metabolic properties. Myogenic progenitors associated with each muscle fiber type are known to intrinsically commit to specific muscle fiber lineage during embryonic development. However, it is still unclear whether the functionality of postnatal adult myogenic cells is attributable to the muscle fiber in which they reside, and whether the characteristics of myogenic cells derived from slow- and fast-type fibers can be distinguished at the genetic level. In this study, we isolated adult satellite cells from slow- and fast-type muscle individually and observed that satellite cells from each type of muscle generated myotubes expressing myosin heavy chain isoforms similar to their original muscle, and showed different metabolic features. Notably, we discovered that slow muscle-derived cells had low potential to differentiate but high potential to self-renew compared with fast muscle-derived cells. Additionally, cell transplantation experiments of slow muscle-derived cells into fast-type muscle revealed that slow muscle-derived cells could better contribute to myofiber formation and satellite cell constitution than fast muscle-derive...Continue Reading

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Citations

Jan 11, 2020·Frontiers in Cell and Developmental Biology·Gunjan Purohit, Jyotsna Dhawan
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hojung ChoiHee-Sook Jun
Apr 6, 2020·Seminars in Cell & Developmental Biology·Pascal MaireMaud Wurmser
Aug 11, 2021·Endocrinology and Metabolism·So-Ichiro Fukada, Ayasa Nakamura

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Methods Mentioned

BETA
PCR
Chip
protein assay

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