Tbx18 regulates the development of the ureteral mesenchyme

The Journal of Clinical Investigation
Rannar AirikAndreas Kispert

Abstract

Congenital malformations of the urinary tract are a major cause of renal failure in children and young adults. They are often caused by physical obstruction or by functional impairment of the peristaltic machinery of the ureter. The underlying molecular and cellular defects are, however, poorly understood. Here we present the phenotypic characterization of a new mouse model for congenital ureter malformation that revealed the molecular pathway important for the formation of the functional mesenchymal coating of the ureter. The gene encoding the T-box transcription factor Tbx18 was expressed in undifferentiated mesenchymal cells surrounding the distal ureter stalk. In Tbx18-/- mice, prospective ureteral mesenchymal cells largely dislocalized to the surface of the kidneys. The remaining ureteral mesenchymal cells showed reduced proliferation and failed to differentiate into smooth muscles, but instead became fibrous and ligamentous tissue. Absence of ureteral smooth muscles resulted in a short hydroureter and hydronephrosis at birth. Our analysis also showed that the ureteral mesenchyme derives from a distinct cell population that is separated early in kidney development from that of other mesenchymal cells of the renal system.

References

Jan 1, 1993·Mechanisms of Development·J F ArmstrongJ B Bard
Aug 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E C Kohaut, A Tejani
Oct 28, 1998·The Journal of Clinical Investigation·Y MiyazakiI Ichikawa
Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B LescherA Kispert
Mar 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A Raatikainen-AhokasH Sariola
Apr 5, 2000·The Journal of Clinical Investigation·Y MiyazakiI Ichikawa
Aug 19, 2000·Seminars in Pediatric Surgery·R W Jennings
Dec 19, 2000·Mechanisms of Development·F KrausA Kispert
Jan 4, 2001·Nature Genetics·E BatourinaC Mendelsohn
Jan 10, 2001·Development, Growth & Differentiation·M Tada, J C Smith
Apr 5, 2001·Mechanisms of Development·K YoshinoA O Perantoni
Mar 23, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Adrian S Woolf, Paul J D Winyard
Jun 26, 2002·BJU International·P Dure-SmithA David
Aug 27, 2002·Nature Genetics·Ekatherina BatourinaCathy L Mendelsohn
Apr 2, 2003·Human Molecular Genetics·Elizabeth A Packham, J David Brook
Oct 3, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoichi Miyazaki, Iekuni Ichikawa
Nov 25, 2003·Seminars in Cell & Developmental Biology·Randy Levinson, Cathy Mendelsohn
Apr 2, 2004·The Journal of Clinical Investigation·Cathy Mendelsohn
Apr 2, 2004·The Journal of Clinical Investigation·Ching-Pin ChangFeng Chen
Jun 18, 2004·Seminars in Perinatology·Robert L Chevalier
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Dec 22, 2004·The Journal of Cell Biology·Xiang-Tian KongTung-Tien Sun
Feb 5, 2005·Developmental Cell·M Albert BassonJonathan D Licht
Nov 16, 2005·Annual Review of Genetics·L A NaicheVirginia E Papaioannou

❮ Previous
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Citations

Dec 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Feng Chen
Aug 28, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Renfang Song, Ihor V Yosypiv
Dec 17, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jason E Cain, Norman D Rosenblum
Jul 19, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pin-Xian Xu
Aug 29, 2012·Cardiovascular Research·Franziska GreulichAndreas Kispert
Jan 8, 2011·Human Molecular Genetics·Antoine ReginensiAndreas Schedl
Apr 19, 2012·Human Molecular Genetics·Mélanie Paces-FessySilvia Cereghini
Mar 3, 2006·The Journal of Clinical Investigation·Cathy Mendelsohn
Feb 23, 2011·The Journal of Clinical Investigation·Jason E CainNorman D Rosenblum
Dec 17, 2009·The International Journal of Developmental Biology·Benchun LiuLaurence S Baskin
Jan 28, 2012·Journal of the American Society of Nephrology : JASN·Piyush TripathiFeng Chen
Feb 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marie-Lyne FillionIndra R Gupta
Dec 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhen X MahoneyWojciech Swat
Aug 4, 2015·American Journal of Human Genetics·Asaf VivanteFriedhelm Hildebrandt
Feb 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stefan KohlFriedhelm Hildebrandt
Dec 22, 2006·Kidney International·D Jenkins, A S Woolf
Jun 15, 2010·Differentiation; Research in Biological Diversity·Gregory TasianLaurence Baskin
Mar 17, 2010·Differentiation; Research in Biological Diversity·Mei CaoLaurence Baskin
Jul 21, 2009·Seminars in Nephrology·Kimberly J Reidy, Norman D Rosenblum
May 6, 2009·Genesis : the Journal of Genetics and Development·Yinqiu WangFeng Chen
Nov 22, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hongrun YuSubburaman Mohan
Feb 15, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Hila Milo Rasouly, Weining Lu
Jan 26, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ashley CarpenterKirk M McHugh
Apr 2, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Winny LiNorman D Rosenblum
Jul 15, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Xin YuanQiang She
Aug 22, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kenneth A WalkerCarlton M Bates
Aug 2, 2011·Developmental Biology·Sheila M BellJeffrey A Whitsett
Jun 28, 2015·Developmental Biology·Elanor N WainwrightPeter Koopman
Aug 5, 2014·Seminars in Cell & Developmental Biology·Tobias Bohnenpoll, Andreas Kispert
Aug 13, 2013·Mechanisms of Development·Xuguang Nie, Lois J Arend
May 24, 2014·Developmental Biology·C Chase BoltLisa Stubbs
Sep 11, 2013·Developmental Biology·San-Pin WuMark W Majesky

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Methods Mentioned

BETA
transgenic
genotyping
dissections

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