Tbx3: another important piece fitted into the pluripotent stem cell puzzle.

Stem Cell Research & Therapy
Melinda K Pirity, Andras Dinnyes

Abstract

Induced pluripotent stem cells (iPSCs) are novel tools for biomedical research, with a promise for future regenerative medicine applications. Recently, Han and colleagues reported in Nature that T box gene 3 (Tbx3) can improve the quality of mouse iPSCs and increase their germline transmission efficacy. This observation contributes greatly to the improvement of iPSC technology and might be a step towards 'designer' reprogramming strategies by generating high quality iPSCs. Further studies comparing pluripotency regulation in different species, including that in human, will be necessary to verify the universal role of Tbx3 and the medical relevance of the observation.

References

Nov 16, 2005·Annual Review of Genetics·L A NaicheVirginia E Papaioannou
Jan 21, 2009·Reproduction, Fertility, and Development·Ian WilmutJane Taylor
Nov 26, 2009·Genes & Development·Fabio SavareseRudolf Grosschedl

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Citations

Mar 13, 2013·Cellular and Molecular Life Sciences : CMLS·Yasuo Takashima, Atsushi Suzuki
Oct 5, 2010·Bioinformatics·Wei HuangSheng Zhong
Aug 13, 2013·PLoS Genetics·Gina P RodriguezGray F Crouse

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Methods Mentioned

BETA
transgenic

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