Tc-99m polyclonal human immunoglobulin G imaging in Graves' ophthalmopathy

Clinical Nuclear Medicine
H DurakB Uysal

Abstract

The authors evaluated the utility of Tc-99m-labeled human immunglobulin G (HIG) in determining the severity of orbital inflammation and the relation of orbital Tc-99m HIG uptake and clinical parameters in patients with Graves' ophthalmopathy. Images were obtained in 23 patients (13 women, 10 men; mean age, 51+/-10 years) with Graves' ophthalmopathy. Planar orbital images were obtained and SPECT was performed using a triple-detector gamma camera 4 hours after 370 MBq (10 mCi) Tc-99m HIG injection. Tc-99m HIG uptake was classified using transaxial and coronal slices as 1, mild; 2, moderate; and 3, severe. The clinical severity of orbital disease was categorized, according to the criteria described by Feldon and Unsold, as class I, mild involvement; class II, moderate; and class III, severe. Disease was considered to be clinically inactive if symptoms and signs were stable or improved in the last two examinations performed at least 6 months apart. Sixteen patients were clinically inactive, and seven patients were active. The mean Tc-99m HIG classes were 1.5+/-0.5 and 2.6+/-0.5, respectively (P = 0.02). There was not a good correlation between the clinical classification and Tc-99m HIG classification, whereas the presence of active...Continue Reading

References

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Citations

Jan 2, 2003·Annals of Nuclear Medicine·Hulya OrtapamukSeniha Naldöken
Aug 24, 2002·Thyroid : Official Journal of the American Thyroid Association·Onur KonukBerati Hasanreisoglu
Apr 10, 2009·Thyroid : Official Journal of the American Thyroid Association·Bernadett UjhelyiEndre V Nagy
Apr 14, 2005·Clinical Nuclear Medicine·A LeondiC Zerva
Aug 31, 2007·Nuclear Medicine Communications·Mehmet ReyhanAyse Aktas
Aug 1, 2011·Molecular Imaging and Radionuclide Therapy·Ozhan OzdoganH Durak
May 11, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A KadanaliM A Tasyaran

Related Concepts

Technetium TC 99m polyclonal IgG
Graves Disease
IgG2B
Lacrimal Gland Structure
Ocular Orbit
Tomography, X-Ray Computerized Axial
Organotechnetium Compounds
Tomography, Emission-Computed, Single-Photon
Radiopharmaceuticals

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