Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Norman YehMark H Kaplan

Abstract

CD8 T cells can acquire cytokine-secreting phenotypes paralleling cytokine production from Th cells. IL-17-secreting CD8 T cells, termed Tc17 cells, were shown to promote inflammation and mediate immunity to influenza. However, most reports observed a lack of cytotoxic activity by Tc17 cells. In this study, we explored the anti-viral activity of Tc17 cells using a vaccinia virus (VV) infection model. Tc17 cells expanded during VV infection, and TCR transgenic Tc17 cells were capable of clearing recombinant VV infection. In vivo, adoptively transferred Tc17 cells lost the IL-17-secreting phenotype, even in the absence of stimulation, but they did not acquire IFN-gamma-secreting potential unless stimulated with a virus-encoded Ag. However, examination of cells following infection demonstrated that these cells acquired cytotoxic potential in vivo, even in the absence of IFN-gamma. Cytotoxic potential correlated with Fasl expression, and the cytotoxic activity of postinfection Tc17 cells was partially blocked by the addition of anti-FasL. Thus, Tc17 cells mediate VV clearance through expression of specific molecules associated with cytotoxicity but independent of an acquired Tc1 phenotype.

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Citations

Jan 18, 2013·PloS One·Veronika SjöbergMarie-Louise Hammarström
Sep 27, 2014·International Reviews of Immunology·Yan LiangDong-Qing Ye
Aug 8, 2013·Journal of Immunotoxicology·Amanda D BuskirkDonald H Beezhold
Dec 11, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jayashree RavichandranCharani Ranasinghe
Jan 1, 2013·Vaccines·Julia TerhuneBrian J Czerniecki
Dec 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antara BanerjeeHira L Nakhasi
Jul 30, 2014·European Journal of Immunology·Mohamed El-BehiBogoljub Ciric
Apr 12, 2014·European Journal of Immunology·Jonas PickMonika C Brunner-Weinzierl
Jul 11, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kai SunWilliam J Murphy
Nov 2, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Hsuan HuangRusung Tan
Aug 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amit SaxenaRoland S Liblau
Jun 1, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Hans-Willi MittrückerMagdalena Huber

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