TcCO2 changes correlate with partial obstruction in children suspected of sleep disordered breathing.

Pediatric Pulmonology
Bebe D'SouzaKaren A Waters

Abstract

Pediatric sleep disordered breathing (SDB) is characterized by long periods of partial upper airway obstruction (UAO) with low apnea-hypopnea indices (AHI). By measuring snoring and stertor, Sonomat studies allow quantification of these periods of partial UAO. To determine whether transcutaneous CO2 (TcCO2 ) levels correlate with increasing levels of partial UAO and to examine patterns of ΔTcCo2 in the transitions from (a) wakefulness to sleep and (b) non-rapid eye movement (NREM) to rapid eye movement (REM) sleep. This was a retrospective review of sleep studies in seven asymptomatic controls aged 7 to 12 years and 62 symptomatic children with suspected SDB and no comorbidities, aged 2 to 13 years. Both groups underwent overnight polysomnography, including continuous TcCO2 , at one of two pediatric hospitals in Sydney. Changes in carbon dioxide levels between wake to NREM (sleep onset) and NREM to REM sleep were evaluated using an all-night TcCO2 trace time-linked to a hypnogram. Paired Sonomat recordings were used to quantify periods of UAO in the symptomatic group. The ΔTcCO2 at sleep onset was greater in SDB children than controls and ΔTcCO2 with sleep onset correlated with the duration of partial obstruction (r = .60; P < ...Continue Reading

References

Nov 1, 1992·The American Review of Respiratory Disease·C L MarcusS L Ward
Aug 1, 1990·Journal of Applied Physiology·K G HenkeJ B Skatrud
Nov 1, 1986·The American Review of Respiratory Disease·T D BradleyE A Phillipson
Aug 1, 1985·Journal of Applied Physiology·J B Skatrud, J A Dempsey
Dec 1, 1993·The American Review of Respiratory Disease·A MorielliR T Brouillette
Jan 28, 2006·American Journal of Respiratory and Critical Care Medicine·Eliot S KatzDavid P White
Jan 9, 2009·The European Respiratory Journal·H SchneiderA R Schwartz
Nov 10, 2013·Respiratory Physiology & Neurobiology·Ville RimpiläOlli Polo
Apr 29, 2014·Sleep & Breathing = Schlaf & Atmung·Jade PautratBrigitte Fauroux
Oct 18, 2015·Respiratory Physiology & Neurobiology·Ville RimpiläOlli Polo
Sep 9, 2016·Current Opinion in Pulmonary Medicine·Christopher A GerdungValerie G Kirk
Sep 9, 2016·European Clinical Respiratory Journal·Ulla AnttalainenTarja Saaresranta
Aug 18, 2018·The European Respiratory Journal·Federica TruccoHui-Leng Tan
Dec 24, 2018·Sleep Medicine·Christian GuilleminaultCaroline Okorie
Mar 3, 2019·Sleep & Breathing = Schlaf & Atmung·Mark B NormanColin E Sullivan
Aug 8, 2019·Journal of Thoracic Disease·Arnaud MariFabrice Vallée
Nov 20, 2019·Medical & Biological Engineering & Computing·Willem van WeteringenPeter M Schumacher

❮ Previous
Next ❯

Citations

Mar 7, 2021·Children·Emanuela di PalmoAndrea Pession
Apr 2, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Clare S MurrayUNKNOWN SLUMBRS Study Advisory Group (SAG) and Respiratory Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.