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TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers

bioRxiv

Jan 8, 2020

Rachel Lena RutishauserPeter W. Hunt

Abstract

Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate secondary effector cells) is a key featur...read more

Mentioned in this Paper

Simian-Human immunodeficiency virus
Cell Growth
Signal Pathways
Primates
Protein Expression
HIV
HIV Infections
Biological Markers
T-Lymphocyte
Stimulation of Antigen Processing and Presentation
10
Paper Details
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TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers

bioRxiv

Jan 8, 2020

Rachel Lena RutishauserPeter W. Hunt

DOI: 10.1101/2020.01.07.894535

Abstract

Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate secondary effector cells) is a key featur...read more

Mentioned in this Paper

Simian-Human immunodeficiency virus
Cell Growth
Signal Pathways
Primates
Protein Expression
HIV
HIV Infections
Biological Markers
T-Lymphocyte
Stimulation of Antigen Processing and Presentation
10

Similar Papers Found In These Feeds

Related Papers

IAVI Report : Newsletter on International AIDS Vaccine Research

Elite controllers found to have more lethal CD8+ T cells

IAVI Report : Newsletter on International AIDS Vaccine ResearchJanuary 1, 2009
Andreas von Bubnoff
Retrovirology

Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options

RetrovirologyMarch 11, 2015
Vijayakumar VeluEsaki M Shankar
Paper Details
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