TCF1 expression marks self-renewing human CD8+ T cells

Blood Advances
Radomir KratchmarovSteven L Reiner

Abstract

Expression of the transcription factor T-cell factor 1 (TCF1) identifies antigen-experienced murine CD8+ T cells that retain potential for lymphoid recirculation and the ability to self-renew while producing more differentiated effector cells. We found that CD8+ T cells in the blood of both healthy and chronically infected humans expressed TCF1 at 3 distinct levels: high (TCF1-hi), intermediate (TCF1-int), and low (TCF1-lo). TCF1-hi cells could be found within both the naive and memory compartments and were characterized by relative quiescence and lack of immediate effector function. A substantial fraction of TCF1-int cells were found among memory cells, and TCF1-int cells exhibited robust immediate effector functions. TCF1-lo cells were most enriched in effector memory cells that expressed the senescence marker CD57. Following reactivation, TCF1-hi cells gave rise to TCF1-lo descendants while self-renewing the TCF1-hi progenitor. By contrast, reactivation of TCF1-lo cells produced more TCF1-lo cells without evidence of de-differentiating into TCF1-hi cells. Flow cytometric analyses of TCF1 expression from patient specimens may become a useful biomarker for adaptive immune function in response to vaccination, infection, autoimm...Continue Reading

References

Jan 30, 2007·Nature Reviews. Immunology·Renata Mazzucchelli, Scott K Durum
Aug 5, 2011·Nature·Brittany Nicole WeberAvinash Bhandoola
Nov 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kristine GermarFotini Gounari
Aug 10, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinyuan Zhou, Hai-Hui Xue
Nov 22, 2013·European Journal of Immunology·Yolanda D MahnkeEnrico Lugli
Nov 10, 2016·Cell Reports·Wen-Hsuan W LinSteven L Reiner
Apr 12, 2017·Nature·Alexander C HuangE John Wherry
Dec 14, 2017·Nature·Ben YoungbloodRafi Ahmed
Dec 29, 2017·The Journal of Experimental Medicine·Arnaud DelpouxStephen M Hedrick

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Citations

Apr 23, 2019·Immunology and Cell Biology·Alexander D McLellan, Seyed M Ali Hosseini Rad
Oct 12, 2019·American Journal of Clinical Dermatology·Emanuelle M RizkYvonne M Saenger
Oct 28, 2019·Frontiers in Immunology·Madhav V Dhodapkar, Kavita M Dhodapkar
May 10, 2020·Nature Communications·Suzanne P M WeltenAnnette Oxenius
May 28, 2020·Frontiers in Immunology·Florent PetitprezWolf H Fridman
Jul 22, 2020·JCI Insight·Jithendra Kini BailurKavita M Dhodapkar
Jul 6, 2020·Science Immunology·Takuya SekineMarcus Buggert
Jul 6, 2019·Viral Immunology·Federico Perdomo-CelisMaría T Rugeles
Sep 10, 2020·International Journal of Molecular Sciences·Chulwoo KimJörg J Goronzy
Jul 2, 2020·Journal for Immunotherapy of Cancer·Bing HuangLequn Li
Oct 21, 2020·Nature Reviews. Immunology·Mohamed A ElTanbouly, Randolph J Noelle
Nov 6, 2020·JCI Insight·Brooke PrinzingStephen Gottschalk
Jan 18, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David H AggenBrian I Rini
Nov 18, 2019·Trends in Immunology·Dinesh RaghuLisa A Mielke
Dec 23, 2020·JCI Insight·Rachel L RutishauserPeter W Hunt
Feb 5, 2021·Cancers·Ali Mehdi, Shafaat A Rabbani
Feb 20, 2021·Immunometabolism·Leena AbdullahYina H Huang
Apr 30, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiaxue ZhangHui Feng
Jun 16, 2021·Nature Reviews. Immunology·Xudong ZhaoHai-Hui Xue
Jun 4, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Reetta VirtakoivuMaija Hollmén
Aug 18, 2021·Journal of Leukocyte Biology·Yutong WangSha Wu
Jun 11, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lam Nhat NguyenZhi Q Yao
Aug 26, 2021·Cell Reports·Jared KlarquistRoss M Kedl
Mar 31, 2021·Cold Spring Harbor Perspectives in Biology·Yuki Muroyama, E John Wherry
Dec 24, 2021·Nature Reviews. Drug Discovery·Alan J KormanNils Lonberg

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