TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes.

BMC Medical Genetics
Swapna MahurkarGiriraj Ratan Chandak

Abstract

Tropical calcific pancreatitis (TCP) is a type of chronic pancreatitis unique to developing countries in tropical regions and one of its important features is invariable progression to diabetes, a condition called fibro-calculous pancreatic diabetes (FCPD), but the nature of diabetes in TCP is controversial. We analysed the recently reported type 2 diabetes (T2D) associated polymorphisms in the TCF7L2 gene using a case-control approach, under the hypothesis that TCF7L2 variants should show similar association if diabetes in FCPD is similar to T2D. We also investigated the interaction between the TCF7L2 variants and N34S SPINK1 and L26V CTSB mutations, since they are strong predictors of risk for TCP. Two polymorphisms rs7903146 and rs12255372 in the TCF7L2 gene were analyzed by direct sequencing in 478 well-characterized TCP patients and 661 healthy controls of Dravidian and Indo-European ethnicities. Their association with TCP with diabetes (FCPD) and without diabetes was tested in both populations independently using chi-square test. Finally, a meta analysis was performed on all the cases and controls for assessing the overall significance irrespective of ethnicity. We dichotomized the whole cohort based on the presence or ab...Continue Reading

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Citations

Aug 22, 2009·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·G RajeshV Balakrishnan
Feb 26, 2011·Journal of Gastroenterology and Hepatology·D Nageshwar Reddy, S Siva Prasad
Jan 14, 2009·World Journal of Gastroenterology : WJG·Swapna MahurkarGiriraj Ratan Chandak
Mar 3, 2012·Digestive Diseases and Sciences·M SasikalaD Nageshwar Reddy
Jun 1, 2010·Best Practice & Research. Clinical Gastroenterology·Monique H M Derikx, Joost P H Drenth
Dec 18, 2014·World Journal of Gastroenterology : WJG·Sumit PaliwalGiriraj R Chandak

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Methods Mentioned

BETA
genotyping

Software Mentioned

Comprehensive Meta Analysis
DeFinitte

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