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TCF7L2 is a master regulator of insulin production and processing

Human Molecular Genetics

Jul 13, 2014

Yuedan ZhouO Hansson

Abstract

Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on is...read more

Mentioned in this Paper

Isl1
Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Biochemical Pathway
Pdx1 protein, rat
PCSK2 gene
Maf Transcription Factors, Large
TCF7L2
Transcription, Genetic
MAFA protein, human
3
126
Paper Details
References
  • References76
  • Citations43
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  • References76
  • Citations43
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Related Papers

The American Journal of Clinical Nutrition

TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women

The American Journal of Clinical NutritionFebruary 13, 2009
Marilyn CornelisFrank B Hu
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TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes

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TCF7L2 is a master regulator of insulin production and processing

Human Molecular Genetics

Jul 13, 2014

Yuedan ZhouO Hansson

PMID: 25015099

DOI: 10.1093/hmg/ddu359

Abstract

Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on is...read more

Mentioned in this Paper

Isl1
Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Biochemical Pathway
Pdx1 protein, rat
PCSK2 gene
Maf Transcription Factors, Large
TCF7L2
Transcription, Genetic
MAFA protein, human
3
126

Similar Papers Found In These Feeds

Genetic Epidemiology Of Complex Diseases

Genetic epidemiology examines the role of genetic factors in determining health and disease in populations and the interaction between these genetic factors with environmental factors. Here is the latest research on the genetic epidemiology of complex multifactorial diseases like cancer.

Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

Related Papers

The American Journal of Clinical Nutrition

TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women

The American Journal of Clinical NutritionFebruary 13, 2009
Marilyn CornelisFrank B Hu
BMC Medical Genetics

TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes

BMC Medical GeneticsFebruary 26, 2011
Andreas HolsteinPeter Kovacs
Paper Details
References
  • References76
  • Citations43
12345...
  • References76
  • Citations43
12345
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