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TCF7L2 is a master regulator of insulin production and processing

bioRxiv

Mar 5, 2014

Yuedan ZhouOla Hansson

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Abstract

Although variants in the T-cell factor 7-like 2 gene (TCF7L2) confer the strongest risk of type 2 diabetes (T2D) by presumed effects on islet function, the underlying mechanisms are not well understood. We have identified TCF7L2-target genes and described the regulatory network downstre...read more

Mentioned in this Paper

NKX6-2 gene
Transcription Factor 7-Like 2
PCSK2 gene
Insulin/Insulin Receptor Signaling Pathway
SLC30A8 protein, human
MAFA protein, human
SLC30A8 gene
INS gene
Assay of Proinsulin
ISL1 protein, human
7
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  • TCF7L2 is a master regulator of insulin production and processing

    bioRxiv

    Mar 5, 2014

    Yuedan ZhouOla Hansson

    PMID: 990003202

    DOI: 10.1101/003202

    Abstract

    Although variants in the T-cell factor 7-like 2 gene (TCF7L2) confer the strongest risk of type 2 diabetes (T2D) by presumed effects on islet function, the underlying mechanisms are not well understood. We have identified TCF7L2-target genes and described the regulatory network downstre...read more

    Mentioned in this Paper

    NKX6-2 gene
    Transcription Factor 7-Like 2
    PCSK2 gene
    Insulin/Insulin Receptor Signaling Pathway
    SLC30A8 protein, human
    7
    Paper Details
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