journal cover

TCF7L2 is a master regulator of insulin production and processing

bioRxiv

Mar 5, 2014

Yuedan ZhouO Hansson

Abstract

Although variants in the T-cell factor 7-like 2 gene ( TCF7L2 ) confer the strongest risk of type 2 diabetes (T2D) by presumed effects on islet function, the underlying mechanisms are not well understood. We have identified TCF7L2-target genes and described the regulatory network downst...read more

Mentioned in this Paper

Diabetes Mellitus, Non-Insulin-Dependent
Biochemical Pathway
T-Lymphocyte
PCSK2 gene
Genes
Insulin/Insulin Receptor Signaling Pathway
Regulation of Biological Process
TCF7L2
PCSK1 protein, human
MAFA protein, human
7
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

Type 2 Diabetes

This feed focuses on Type 2 Diabetes, a disease where the body doesn’t produce or respond to insulin anymore, leading to abnormal glucose levels in the blood.

Proinsulin & Type 2 Diabetes

Proinsulin, a prohormone precursor to insulin, is produced in beta cells of pancreatic islets. Here is the latest research on proinsulin in type 2 diabetes.

Type 2 Diabetes (Preprints)

This feed focuses on Type 2 Diabetes, a disease where the body doesn’t produce or respond to insulin anymore, leading to abnormal glucose levels in the blood.

Type 1 Diabetes (Preprints)

Type 1 diabetes is a chronic disease characterized by progressive immune-mediated destruction of insulin-producing beta cells in pancreatic islets. Here is the latest research.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Antidiabetic Cellular Plasticity

This feed focuses on mechanisms that underlie cellular plasticity as a treatment for diabetes and other degenerative diseases.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

© 2020 Meta ULC. All rights reserved

TCF7L2 is a master regulator of insulin production and processing

bioRxiv

Mar 5, 2014

Yuedan ZhouO Hansson

PMID: 990003202

DOI: 10.1101/003202

Abstract

Although variants in the T-cell factor 7-like 2 gene ( TCF7L2 ) confer the strongest risk of type 2 diabetes (T2D) by presumed effects on islet function, the underlying mechanisms are not well understood. We have identified TCF7L2-target genes and described the regulatory network downst...read more

Mentioned in this Paper

Diabetes Mellitus, Non-Insulin-Dependent
Biochemical Pathway
T-Lymphocyte
PCSK2 gene
Genes
Insulin/Insulin Receptor Signaling Pathway
Regulation of Biological Process
TCF7L2
PCSK1 protein, human
MAFA protein, human
7

Similar Papers Found In These Feeds

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/tcf7l2-is-a-master-regulator-of-insulin/990003202