Tcf/Lef transcription factors during T-cell development: unique and overlapping functions

The Hematology Journal : the Official Journal of the European Haematology Association
Frank J T Staal, Hans Clevers

Abstract

The founding members of the TCF family are T-cell factor-1 (Tcf-1) and lymphoid enhancing factor-1 (Lef-1). In adult mammals, Tcf-1 is uniquely expressed in T lymphocytes, while Lef-1 is expressed in T cells and early B cells. During murine development, however, expression of Tcf-1 and Lef-1 occurs in complex overlapping patterns in many tissues. The unique in vivo function of Tcf-1 and Lef-1 have been explored by gene disruption experiments. Tcf-1-/- knockout mice are severely impaired in the generation of T cells, but are otherwise normal. Lef-1-/- mice lack hair, teeth, mammary glands and trigeminal nuclei and as a consequence die around birth. As deduced from direct analyses and from transplantation experiments, the Lef-1 mutation has no major effects on the immune system. In Tcf-1/Lef-1 double knockout mice, development of T cells is completely abrogated, indicating that Lef-1 can substitute for Tcf-1 in T-cell differentiation. Factors of the TCF/LEF HMG domain family (TCFs) exist throughout the animal kingdom. It has become evident that the TCFs interact with the vertebrate Wnt effector beta-catenin to mediate axis formation in Xenopus. Likewise, Armadillo (the Drosophila ortholog of beta-catenin) is genetically upstream ...Continue Reading

Citations

Feb 1, 2005·Genes & Development·Renée van AmerongenAnton Berns
Jun 26, 2007·Cells, Tissues, Organs·Christoph A GebeshuberStefan Grunert
Aug 20, 2019·Cell Communication and Signaling : CCS·Yudan WangFaming Tian
Nov 7, 2019·Oxidative Medicine and Cellular Longevity·Yabing Xiong, Lili Zhou
Apr 17, 2003·BMC Genomics·Emmett O'Flaherty, Jonathan Kaye
Jun 5, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert L JilkaStavros C Manolagas
Mar 8, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Raluca Pancratov, Ramanuj DasGupta
Oct 26, 2010·Immunological Reviews·Ellen V RothenbergLong Li
Dec 3, 2015·Annals of the New York Academy of Sciences·Wanqing XieDi Chen
Mar 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Foster C GonsalvesRamanuj DasGupta
Jul 6, 2014·British Journal of Haematology·Smita DandekarWilliam L Carroll
Sep 30, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yadong WangYisheng Wang
Jul 29, 2017·Current Rheumatology Reports·Yachuan ZhouDi Chen
Oct 13, 2017·International Journal of Molecular Sciences·Ye TianAi-Rong Qian
Jan 18, 2015·Molecular & Cellular Proteomics : MCP·Bjoern TraenkleUlrich Rothbauer
Sep 21, 2006·Molecular Cancer Therapeutics·Kang Hyun ChoiSunjoo Jeong
Nov 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Parisa Vahidi FerdowsiStephen Myers
Feb 14, 2006·Biochemical and Biophysical Research Communications·Yukiteru OujiShigeaki Ishizaka
Mar 3, 2006·Biochemical and Biophysical Research Communications·Yukiteru OujiShigeaki Ishizaka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.