TCONS_00483150 as a novel diagnostic biomarker of systemic lupus erythematosus.

Epigenomics
Gangqiang GuoHuidi Zhang

Abstract

Aim: We aimed to identify differentially expressed Long noncoding RNAs (lncRNAs) and explore their functional roles in systemic lupus erythematosus (SLE). Materials & methods: We identified dysregulated lncRNAs and investigated their prognostic values and potential functions using MiRTarget2, catRAPID omics and Bedtools/blast/Pearson analyses. Results: Among the 143 differentially expressed lncRNAs, TCONS_00483150 could be used to distinguish patients with SLE from healthy controls and those with rheumatoid arthritis and patients with active/stable SLE from healthy controls. TCONS_00483150 was significantly correlated with anti-Rib-P antibody positivity and low C3 levels; TCONS_00483150 dysregulation might contribute to the metabolism of RNA and proteins in SLE patients. Conclusion: Overall, our findings offer a transcriptome-wide overview of aberrantly expressed lncRNAs in patients with SLE and highlight TCONS_00483150 as a potential novel diagnostic biomarker.

References

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Methods Mentioned

BETA
PCR
electrophoresis
interaction prediction

Software Mentioned

SPSS
catRAPID express
MetaCore
Bedtools
miRanda
MedCalc
R
BLAST
catRAPID
catRAPID omics

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