TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling.

Frontiers in Immunology
Sun Taek KimEllis L Reinherz

Abstract

Mechanotransduction is a basis for receptor signaling in many biological systems. Recent data based upon optical tweezer experiments suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into biochemical signals upon specific peptide-MHC complex (pMHC) ligation. Tangential force applied along the pseudo-twofold symmetry axis of the TCR complex post-ligation results in the αβ heterodimer exerting torque on the CD3 heterodimers as a consequence of molecular movement at the T cell-APC interface. Accompanying TCR quaternary change likely fosters signaling via the lipid bilayer predicated on the magnitude and direction of the TCR-pMHC force. TCR glycans may modulate quaternary change, thereby altering signaling outcome as might the redox state of the CxxC motifs located proximal to the TM segments in the heterodimeric CD3 subunits. Predicted alterations in TCR TM segments and surrounding lipid will convert ectodomain ligation into the earliest intracellular signaling events.

Citations

Sep 6, 2013·Annals of Biomedical Engineering·Cheng Zhu
Aug 20, 2014·Nature Immunology·Arup K Chakraborty, Arthur Weiss
Feb 11, 2015·The Journal of Cell Biology·William A ComrieJanis K Burkhardt
Mar 26, 2016·Frontiers in Immunology·William A Comrie, Janis K Burkhardt
Jan 3, 2013·Immunological Reviews·Cheng ZhuBrian D Evavold
Oct 15, 2013·Immunological Reviews·Alexander Babich, Janis K Burkhardt
Oct 15, 2013·Immunological Reviews·Wei Chen, Cheng Zhu
Sep 22, 2015·Frontiers in Immunology·Kristine N BrazinEllis L Reinherz
May 6, 2015·Progress in Biophysics and Molecular Biology·Wei WuChenqi Xu
Apr 12, 2015·Annual Review of Immunology·Bernard Malissen, Pierre Bongrand
May 18, 2013·Biochimica Et Biophysica Acta·Sudha KumariMichael L Dustin
Dec 3, 2014·Biochimica Et Biophysica Acta·Enrico KlotzschKatharina Gaus
Feb 23, 2017·Annual Review of Immunology·Arup K Chakraborty
Aug 26, 2016·Lab on a Chip·Patrícia Moura RosaØyvind Halaas
Mar 26, 2013·Nature Reviews. Immunology·Rebecca J Brownlie, Rose Zamoyska
Apr 27, 2017·Scientific Reports·Jose FaroCarmen Molina-París
Jun 29, 2012·Nature·Ellis L Reinherz
May 21, 2020·International Journal of Molecular Sciences·Yuanqing MaKatharina Gaus
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yinnian FengMatthew J Lang
Jun 9, 2020·Frontiers in Immunology·Nayan D Bhattacharyya, Carl G Feng
Dec 7, 2018·Frontiers in Immunology·Jérémie RossyDaniel F Legler
Dec 31, 2020·International Journal of Molecular Sciences·Christopher SzetoStephanie Gras
Mar 3, 2021·Science Immunology·Jacqueline DouglassShibin Zhou
Mar 26, 2021·Scientific Reports·Anaïs SadounPierre-Henri Puech
Jul 21, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Alexander S ZhovmerErdem D Tabdanov
Jan 19, 2021·ACS Biomaterials Science & Engineering·Lital MordechayMark Schvartzman

❮ Previous
Next ❯

Methods Mentioned

BETA
peptide mapping
glycosylation
NMR
X-ray
optical tweezers
transgenic
fluorescence imaging

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved