TCR Repertoire Changes during TIL Expansion: Clonal Selection or Drifting?

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Maria Lozano-Rabella, Alena Gros

Abstract

T-cell receptor β analysis can be exploited to monitor changes in the clonotypic composition of tumor-infiltrating lymphocyte (TIL) during ex vivo expansion in IL2. Oligoclonal TILs are often outgrown by infrequent clonotypes with greater proliferative capacity, and this could impact the antitumor reactivity of the expanded TILs.See related article by Poschke et al., p. 4289.

References

Mar 29, 2014·The Journal of Clinical Investigation·Alena GrosSteven A Rosenberg
Mar 24, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rikke AndersenInge Marie Svane
Jun 30, 2016·Cancer Immunology Research·Anna PasettoSteven A Rosenberg
Oct 1, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U DafniG Coukos
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U DafniG Coukos
Apr 19, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Isabel C PoschkeRienk Offringa

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