TCR repertoire profiling of tumors, adjacent normal tissues, and peripheral blood predicts survival in nasopharyngeal carcinoma

Cancer Immunology, Immunotherapy : CII
Ya-Bin JinYue-Jian Wang

Abstract

The T-cell immune responses in nasopharyngeal carcinoma patients have been extensively investigated recently for designing adoptive immunotherapy or immune checkpoint blockade therapy. However, the distribution characteristics of T cells associated with NPC pathogenesis are largely unknown. We performed deep sequencing for TCR repertoire profiling on matched tumor/adjacent normal tissue from 15 NPC patients and peripheral blood from 39 NPC patients, 39 patients with other nasopharyngeal diseases, and 33 healthy controls. We found that a lower diversity of TCR repertoire in tumors than paired tissues or a low similarity between the paired tissues was associated with a poor prognosis in NPC. A more diverse TCR repertoire was identified in the peripheral blood of NPC patients relative to the controls; this was related to a significant decrease in the proportion of high-frequency TCR clones in NPC. Higher diversity in peripheral blood of NPC patients was associated with a worse prognosis. Due to the peculiarity of the Vβ gene usage patterns in the peripheral blood of NPC patients, 15 Vβ genes were selected to distinguish NPC patients from controls by the least absolute shrinkage and selection operator analysis. We identified 11 clo...Continue Reading

References

Aug 4, 1988·Nature·M M Davis, P J Bjorkman
Nov 5, 1999·Science·T P ArstilaP Kourilsky
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sing-fai LeungAnthony T C Chan
Feb 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mark H FoggFred Wang
Jun 23, 2009·Genome Research·J Douglas FreemanRobert A Holt
Sep 3, 2010·Science Translational Medicine·Harlan S RobinsEdus H Warren
Apr 14, 2011·Experimental Biology and Medicine·Caroline Jochems, Jeffrey Schlom
Jan 4, 2012·Cell Research·Hanjie LiJiahuai Han
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Sep 25, 2012·Cancer Research·Charles Swanton
Nov 1, 2013·Genome Medicine·Daniel J WoodsworthRobert A Holt
Nov 13, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Simon TurcotteSteven A Rosenberg
Mar 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lidia RobertAntoni Ribas
Apr 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ivan V ZvyaginIlgar Z Mamedov
May 30, 2014·Science Translational Medicine·Edward ChaLawrence Fong
Jun 24, 2014·Nature Biotechnology·Arnold HanMark M Davis
Jan 27, 2015·Cellular & Molecular Immunology·Meriem AttafAndrew K Sewell
May 13, 2015·Seminars in Oncology·Edward ChaMarcin Kowanetz
Aug 11, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Evaggelia LiaskouGideon M Hirschfield
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff P BruceFei-Fei Liu
May 4, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yan-Qi HuangZai-Yi Liu
Jun 24, 2016·Journal of the National Cancer Institute·Michael D IglesiaBenjamin G Vincent
Feb 19, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicolas A GiraldoCatherine Sautès-Fridman

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Citations

Jan 24, 2020·Pigment Cell & Melanoma Research·Julie CharlesCaroline Aspord
Sep 9, 2020·Nature Biotechnology·Pierre BarennesEncarnita Mariotti-Ferrandiz
Jun 19, 2021·Computational and Structural Biotechnology Journal·Danyi XiongXinlei Wang
Jul 30, 2021·Frontiers in Immunology·Daniel BodeDavid G Kent

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