TCR-Seq Identifies Distinct Repertoires of Distant-Metastatic and Nondistant-Metastatic Thyroid Tumors.

The Journal of Clinical Endocrinology and Metabolism
Xiabin LanMinghua Ge

Abstract

Malignant thyroid tumor with distant metastasis is associated with poor outcome. Early detection of distant metastasis is of great clinical importance. Thyroid tumor infiltrated with T cells can serve as a biomarker for monitoring metastasis. A retrospective analysis was performed of patient clinical samples collected between 2012 to 2018, using T-cell receptor sequencing (TCR-seq) for clinical exploration. This study took place at Zhejiang Cancer Hospital. Sixty-eight patients with papillary thyroid cancer (PTC) (distinct metastatic status) and 21 patients with benign nodules were enrolled. All patients had not received any treatment before surgery. The characteristics of TCRβ complementary-determining region 3 (CDR3) for each patient were determined by high-throughput sequencing. The TCRβ diversity of malignant tumors is significantly higher than benign nodules both in blood and tumor samples (Shannon index, blood, P < .01; tumor, P < .001). The malignant tumors with distant metastasis or invasiveness showed lower TCRβ diversity than nonmetastasis (Shannon index, P < .01) or noninvasive (Shannon index, P < .01) malignant tumors. Analysis of the Morisita-Horn similarity index indicated significant TCRβ repertoire similarity be...Continue Reading

References

Feb 1, 1990·Postgraduate Medical Journal·A W GooldenC Pease
Jul 1, 1987·The British Journal of Surgery·H R MichieG Glazer
Jan 1, 1994·Journal of Neuro-oncology·B M BiswalG K Rath
Oct 12, 2004·Clinical Endocrinology·A P Weetman
Nov 18, 2006·Nature Reviews. Immunology·Stephen J TurnerJamie Rossjohn
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Diana S Dean, Hossein Gharib
Oct 23, 2009·American Journal of Clinical Pathology·Edmund S CibasUNKNOWN NCI Thyroid FNA State of the Science Conference
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Sep 29, 2011·Journal of Immunological Methods·Harlan RobinsKaren Cerosaletti
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Jul 26, 2012·Thyroid : Official Journal of the American Thyroid Association·Iain J NixonIan Ganly
Aug 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Marina N NikiforovaYuri E Nikiforov
Feb 22, 2014·JAMA Otolaryngology-- Head & Neck Surgery·Louise Davies, H Gilbert Welch
May 30, 2014·Science Translational Medicine·Edward ChaLawrence Fong
Nov 25, 2014·Cell·UNKNOWN Cancer Genome Atlas Research Network
Feb 1, 2015·Biochemical and Biophysical Research Communications·Qian ZhangLongkun Li
Apr 30, 2015·Nature Methods·Dmitriy A BolotinDmitriy M Chudakov
May 25, 2015·Cancer Discovery·Nirupa MurugaesuCharles Swanton
Jul 3, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Louise DaviesUNKNOWN AACE Endocrine Surgery Scientific Committee
May 31, 2016·American Journal of Human Genetics·Abdul K SirajKhawla S Al-Kuraya
May 31, 2016·Nature Genetics·Bo LiX Shirley Liu
Nov 2, 2016·Thyroid : Official Journal of the American Thyroid Association·Joseph J WiltshireSabapathy P Balasubramanian
Nov 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·John F BeausangStephen R Quake
Jan 22, 2019·International Journal of Cancer. Journal International Du Cancer·Yang-Yang LiuLi Liu

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