TCR signal strength controls the differentiation of CD4+ effector and memory T cells

Science Immunology
Jeremy P SnookMatthew A Williams

Abstract

CD4+ T cell responses are composed of heterogeneous T cell receptor (TCR) signals that influence the acquisition of effector and memory characteristics. We sought to define early TCR-dependent activation events that control T cell differentiation. A polyclonal panel of TCRs specific for the same viral antigen demonstrated substantial variability in TCR signal strength, expression of CD25, and activation of nuclear factor of activated T cells and nuclear factor κB. After viral infection, strong TCR signals corresponded to T helper cell (TH1) differentiation, whereas T follicular helper cell and memory T cell differentiation were most efficient when TCR signals were comparatively lower. We observed substantial heterogeneity in TCR-dependent CD25 expression in vivo, and the vast majority of CD4+ memory T cells were derived from CD25lo effector cells that displayed decreased TCR signaling in vivo. Nevertheless, memory T cells derived from either CD25lo or CD25hi effector cells responded vigorously to rechallenge, indicating that, although early clonal differences in CD25 expression predicted memory T cell numbers, they did not predict memory T cell function on a per cell basis. Gene transcription analysis demonstrated expression cl...Continue Reading

References

Nov 1, 1995·The Journal of Experimental Medicine·S ConstantK Bottomly
Sep 11, 1995·Journal of Immunological Methods·T ZhumabekovD Kioussis
Nov 1, 1993·The Journal of Experimental Medicine·M WoodrowD Cantrell
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer L BrogdonKim Bottomly
Jun 11, 2003·Nature Immunology·Norihiko WatanabeKenneth M Murphy
Jul 4, 2003·Nature·J Rodrigo MoraUlrich H Von Andrian
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katharina M HusterDirk H Busch
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew A Williams, Michael J Bevan
Apr 19, 2005·Nature Immunology·Meredith SaffordJonathan D Powell
May 18, 2005·The Journal of Experimental Medicine·Reinhard ObstChristophe Benoist
Sep 9, 2005·The Journal of Experimental Medicine·Dawn M Jelley-GibbsSusan L Swain
Nov 30, 2006·Annual Review of Immunology·Matthew A Williams, Michael J Bevan
Apr 5, 2007·Nature Protocols·Jeff HolstDario A A Vignali
Mar 3, 2009·Nature Immunology·Nicolas FazilleauMichael G McHeyzer-Williams
Jan 20, 2010·Nature Immunology·Shane CrottyStephen P Schoenberger
Mar 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Youn Soo ChoiShane Crotty
Jul 24, 2013·The Journal of Experimental Medicine·Marc Martínez-LlordellaJeffrey A Bluestone
Nov 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinya TanakaChen Dong
May 12, 2015·Nature Communications·SuJin HwangPaul E Love
Oct 21, 2015·The Journal of Experimental Medicine·Arvind ShakyaDean Tantin
May 12, 2017·Current Opinion in Biotechnology·Michael T Bethune, Alok V Joglekar

❮ Previous
Next ❯

Citations

Dec 5, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dmitri I KotovMarc K Jenkins
Mar 22, 2019·Immunology·Quynh P NguyenAnanda W Goldrath
Mar 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dmitri I KotovMarc K Jenkins
May 24, 2019·Immunology and Cell Biology·Megan Sf SoonAshraful Haque
May 16, 2019·Current Protocols in Immunology·Yuelin KongMaria Bettini
Feb 29, 2020·Cells·Itay RaphaelThomas G Forsthuber
Aug 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabrina SoloukiAvery August
Jul 9, 2020·Clinical and Experimental Immunology·A Ahmed, A Vyakarnam
Jun 7, 2020·Cancer Immunology, Immunotherapy : CII·Charlotte M MoussetHarry Dolstra
Jun 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Courtney A MatsonNevil J Singh
Jul 9, 2020·Frontiers in Immunology·Xianhui MengJie Sun
Apr 22, 2020·Cellular & Molecular Immunology·Luca DanelliGeorge Kassiotis
Apr 29, 2020·Annual Review of Immunology·Mikel RuterbuschMarion Pepper
Jun 9, 2020·Frontiers in Immunology·Nayan D Bhattacharyya, Carl G Feng
Apr 10, 2020·Frontiers in Cellular and Infection Microbiology·Marc Brillantes, Aimee M Beaulieu
May 28, 2020·Frontiers in Immunology·Ankita MitraBarbara A Osborne
Sep 30, 2020·Nature Immunology·Juliet M BartlesonPaul M Allen
Sep 10, 2020·International Journal of Molecular Sciences·Chulwoo KimJörg J Goronzy
Oct 9, 2020·International Journal of Molecular Sciences·Daniel J VerdonMisty R Jenkins
Nov 17, 2020·Frontiers in Immunology·Marlene E ReinckeBaerbel Keller
Jan 13, 2021·International Journal of Molecular Sciences·Jérôme Kervevan, Lisa A Chakrabarti
Feb 7, 2021·Cancers·Jennifer R RichardsonJuliane Schuhmacher
Feb 17, 2021·The FEBS Journal·Huimin ZhangJörg J Goronzy
Mar 6, 2021·Trends in Immunology·Jinyong Choi, Shane Crotty
Mar 9, 2021·Frontiers in Immunology·Iwona Monika SzopaKinga Majchrzak-Kuligowska
May 11, 2020·The Journal of Allergy and Clinical Immunology·Claire E GustafsonJörg J Goronzy
Dec 5, 2020·Seminars in Immunology·Rémi Fromentin, Nicolas Chomont
May 30, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nayan D BhattacharyyaCarl G Feng
Jun 17, 2021·Immunity & Ageing : I & a·Chulwoo KimJörg J Goronzy
Jul 12, 2021·Seminars in Cell & Developmental Biology·Imke LieboldLidia Bosurgi
Mar 24, 2021·Cold Spring Harbor Perspectives in Biology·Takeshi KawabeJonathan Sprent
Oct 6, 2021·International Reviews of Immunology·Natalija NovakBeatriz Cabanillas
Apr 28, 2021·Cold Spring Harbor Perspectives in Biology·Peter D KruegerMarc K Jenkins
Dec 21, 2021·Frontiers in Veterinary Science·Ellen E SpargerMichael S Kent
Nov 24, 2021·The Journal of Clinical Investigation·Brinda MonianJ Christopher Love

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