Abstract
To study V beta gene expression in oral lichen planus (OLP) lesional T lymphocytes cell lines. Lesional T lymphocytes were isolated from eight OLP patients and cell lines established. The total RNA was extracted from these lymphocyte cell lines and reverse transcribed. cDNA was amplified by the polymerase chain reaction (PCR) using a panel of 26 V beta-specific oligonucleotide primers followed by qualitative analysis of the electrophoresed reaction products. V beta 1, 2, 3, 5.1, 6.1-3, 7, 8, 9, 22, 23, and 24 were represented consistently in all of the OLP samples, V beta 11, 12, and 17 were consistently negative, while the other V beta families (V beta 4, 5.2-3, 10, 13.1, 13.2, 14, 15, 16, 18, 19, 20, and 21) were variable. V beta 22 and 23 were the most strongly expressed in all patients. A limited T cell receptor (TCR) gene usage indicates a degree of oligoclonality within these lesional T lymphocyte cell lines from OLP. This implies that OLP may be an antigen-specific disease or linked to a limited number of superantigens.
References
May 1, 1992·Journal of Clinical Immunology·C G Drake, B L Kotzin
Sep 1, 1992·Immunology Today·C MarguerieA So
Feb 1, 1992·Infection and Immunity·M A TomaiM Kotb
Apr 1, 1992·Arthritis and Rheumatism·R BaccalaA N Theofilopoulos
May 1, 1992·European Journal of Immunology·C GenevéeT Hercend
May 1, 1992·Transplantation·B L Hall, O J Finn
Apr 1, 1991·Arthritis and Rheumatism·S M FriedmanM K Crow
Oct 1, 1991·The Journal of Experimental Medicine·S M FriedmanD N Posnett
Jul 19, 1991·Science·X PaliardB L Kotzin
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J K RussellH M Johnson
May 11, 1990·Science·P Marrack, J Kappler
Oct 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L J WalshG J Seymour
Apr 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L SalonenL Helldén
Sep 21, 1990·Cell·P DellabonaD Mathis
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y W ChoiJ Kappler
Jan 13, 1989·Cell·J WhiteP Marrack
May 19, 1989·Science·J KapplerP Marrack
Jan 1, 1989·Archives of Dermatological Research·J D BosM L Kapsenberg
Apr 1, 1988·International Journal of Oral and Maxillofacial Surgery·S C LinH W Kwan
Jul 1, 1985·Journal of Oral Pathology·C Scully, M el-Kom
Feb 1, 1993·The Journal of Experimental Medicine·J A MollickR R Rich
Oct 1, 1993·The Journal of Investigative Dermatology·C Hauser, H A Orbea
Jan 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P B SugermanG J Seymour
Sep 1, 1994·The British Journal of Dermatology·P B SugermanG J Seymour
Dec 1, 1994·Clinical and Experimental Immunology·C Simark-MattssonU I Dahlgren
Apr 1, 1994·Scandinavian Journal of Immunology·K E LundinT Hansen
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A A GromD N Glass
Jan 1, 1993·The Australasian Journal of Dermatology·P B SugermanG J Seymour
Jan 1, 1993·Advances in Immunology·B L KotzinP Marrack
Jan 1, 1993·The Journal of Experimental Medicine·K R HudsonJ D Fraser
Mar 1, 1993·Annals of the Rheumatic Diseases·H Acha-Orbea
May 1, 1993·The Journal of Infectious Diseases·P M Schlievert
Mar 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P B SugermanG J Seymour
Citations
Jan 1, 1999·Oral Microbiology and Immunology·E GemmellG J Seymour
Mar 29, 2000·The British Journal of Dermatology·P B SugermanM Bigby
Feb 18, 2003·Australian Dental Journal·P B Sugerman, N W Savage
Mar 25, 2014·BMC Pulmonary Medicine·Kerstin M AhlgrenJohan Grunewald
Jun 22, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Z Z ZhaoL J Walsh
Jun 6, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K ThongprasomC Boonjatturus
Dec 16, 2003·Skinmed·Claudio de Moura Castro JacquesMarcia Ramos-e-Silva
Sep 11, 2008·Clinical and Experimental Immunology·A GotohR Suzuki
Apr 16, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·E KawamuraK Shirasuna
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P B SugermanM Bigby
Jan 3, 2001·Clinics in Dermatology·P B SugermanM Bigby