PMID: 7536011Dec 1, 1994Paper

TCR V gene usage in autoimmunity

Current Opinion in Immunology
D P Gold

Abstract

With the use of polymerase chain reaction technology, investigators now have the ability to assess, in a comprehensive and rapid manner, the entire repertoire of T cell antigen receptors expressed by pathogenic cells present in virtually any disease site. A summary of studies of T cell receptor variable gene usage suggests that preferential expression can be identified most reproducibly when cells are isolated directly from pathogenic lesions. This provides a framework for future investigations in other autoimmune settings.

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Feb 15, 1996·Journal of Neuroscience Research·A A VandenbarkH Offner
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