TDAE-assisted synthesis of new imidazo[2,1-b]thiazole derivatives as anti-infectious agents

European Journal of Medicinal Chemistry
Thierry JuspinPatrice Vanelle

Abstract

A series of new imidazo[2,1-b]thiazoles was prepared in moderate to good yields in a four step synthesis using the TDAE methodology from 6-chloromethyl-5-nitroimidazo[2,1-b]thiazole and keto esters, ketomalonates and ketolactams. All compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two Gram positive and two Gram negative ones) and four yeasts. Among these synthesized 5-nitroimidazo[2,1-b]thiazoles, the compounds 1 and 6 showed potent antimicrobial activities against all candida strains and compound 3e showed an interesting antifungal potential against Candida tropicalis.

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Citations

Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Mehmet AkkurtOrhan Büyükgüngör
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Mehmet AkkurtShahzad Sharif
May 17, 2012·Acta Crystallographica. Section E, Structure Reports Online·Mehmet AkkurtMuhammad Nawaz Tahir
Oct 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alain Gamal Giuglio-TonoloPatrice Vanelle
Apr 25, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huaiwei DingChunyan Tan
Jan 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aïda R Nadji-BoukrouchePatrice Vanelle
Nov 26, 2013·Angewandte Chemie·Julie BroggiPatrice Vanelle
Jun 27, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Felix GlaserOliver S Wenger

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