TDM in psychiatry and neurology: A comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians<sup/>

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Georgios SchoretsanitisC Hiemke

Abstract

Therapeutic drug monitoring (TDM) combines the quantification of drug concentrations in blood, pharmacological interpretation and treatment guidance. TDM introduces a precision medicine tool in times of increasing awareness of the need for personalized treatment. In neurology and psychiatry, TDM can guide pharmacotherapy for patient subgroups such as children, adolescents, pregnant women, elderly patients, patients with intellectual disabilities, patients with substance use disorders, individuals with pharmacokinetic peculiarities and forensic patients. Clear indications for TDM include lack of clinical response in the therapeutic dose range, assessment of drug adherence, tolerability issues and drug-drug interactions. Based upon existing literature, recommended therapeutic reference ranges, laboratory alert levels, and levels of recommendation to use TDM for dosage optimization without specific indications, conversion factors, factors for calculation of dose-related drug concentrations and metabolite-to-parent ratios were calculated. This summary of the updated consensus guidelines by the TDM task force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie offers the practical and theoretical knowledg...Continue Reading

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Citations

Jul 31, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dario CattaneoCristina Gervasoni
Nov 20, 2018·Expert Review of Clinical Pharmacology·Georgios SchoretsanitisJose de Leon
Nov 6, 2018·Drug Metabolism and Personalized Therapy·Ana E Rodríguez VicenteAna M Peiró
Feb 26, 2019·Clinical Pharmacology and Therapeutics·Jacob T BrownJ Steven Leeder
May 17, 2019·International Clinical Psychopharmacology·Christoph KowalewskiGeorgios Schoretsanitis
Mar 3, 2020·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Jose de LeonCan-Jun Ruan
Apr 3, 2020·Expert Opinion on Drug Metabolism & Toxicology·Georgios SchoretsanitisAndreas A Westin
Apr 21, 2020·Basic & Clinical Pharmacology & Toxicology·Maxim KuzinMichael Paulzen
Jun 2, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Rainer Rupprecht
Mar 21, 2020·Frontiers in Pharmacology·Thierry BuclinLaurent A Decosterd
Aug 7, 2019·Dose-response : a Publication of International Hormesis Society·Hugo Juárez Olguín
Jun 18, 2019·Journal of Clinical Psychopharmacology·Jaqueline BarclayJose de Leon
Jan 7, 2020·Mass Spectrometry Reviews·Jia-Jia CuiJi-Ye Yin
Feb 16, 2021·Journal of Clinical Psychopharmacology·Domenico De DonatisLaura Mercolini
Jun 3, 2021·International Journal of Molecular Sciences·Kouji Fukuyama, Motohiro Okada
Jun 8, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Domenico De DonatisVincenzo Florio
Jun 29, 2021·International Journal of Psychiatry in Medicine·Ian R McGraneMichael D Shuman

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