TDP-43 and Alzheimer's Disease Pathologic Subtype in Non-Amnestic Alzheimer's Disease Dementia

Journal of Alzheimer's Disease : JAD
Aradhana SahooK A Josephs

Abstract

TDP-43 has been shown to be strongly associated with memory loss, smaller hippocampal volumes, and faster rates of hippocampal atrophy in Alzheimer's disease (AD) patients with an amnestic presentation. Whether TDP-43 has any clinical or anatomical associations in AD patients with non-amnestic phenotype is unknown. To determine whether TDP-43 plays a significant role in the clinic-anatomic features of non-amnestic AD. All cases with pathologically confirmed intermediate-high probability AD from 1996-2012 were identified and retrospectively sub-classified into amnestic versus non-amnestic dementia at the time of presentation. Neurofibrillary tangle counts were performed in those with a non-amnestic presentation using thioflavin-S microscopy in the hippocampus and three neocortical regions, and all cases were subtyped into hippocampal-sparing, limbic-predominant, and typical AD pathology. TDP-43 immunoreactivity was used to assess for the presence of TDP-43. Statistical analyses helped determine whether pathologic subtype or TDP-43 was more strongly associated with clinico-imaging features. Out of 172 pathologically confirmed AD cases, 36 (19%) were classified as non-amnestic. Twenty-five of these 36 (69%) had typical pathology, ...Continue Reading

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Citations

Apr 16, 2020·Annals of Clinical and Translational Neurology·Keith A JosephsJennifer L Whitwell
May 1, 2019·Brain : a Journal of Neurology·Peter T NelsonJulie A Schneider
Mar 12, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jennifer L WhitwellKeith A Josephs
Apr 30, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Somin KwonEliezer Masliah
Aug 3, 2020·Journal of Neural Transmission·Kurt A Jellinger
Aug 25, 2020·Brain : a Journal of Neurology·John L RobinsonPeter T Nelson
Dec 9, 2020·Journal of Alzheimer's Disease : JAD·Thomas G Beach, Michael Malek-Ahmadi
Mar 21, 2021·Brain : a Journal of Neurology·Patricia A BoyleDavid A Bennett
Jan 12, 2021·Dementia and Geriatric Cognitive Disorders·Kurt A Jellinger
Dec 18, 2021·Journal of Neural Transmission·Kurt A Jellinger

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