PMID: 8950350Nov 4, 1996Paper

Tea polyphenols as inhibitors of mutagenicity of major classes of carcinogens

Mutation Research
J H WeisburgerE Zang

Abstract

Previous research suggested that the mutagenicity of some genotoxic carcinogens, mainly heterocyclic amines, was decreased by green or black tea extracts, or tea polyphenol fractions. Thus, it seemed important to test a variety of genotoxic carcinogens with distinct chemical structures and means of biochemical activation as regards modification of mutagenicity in appropriate strains of Salmonella typhimurium by 3 concentrations of polyphenols 60, 100, or B, standard commercial polyphenol preparations from green or black tea. Polyphenols sharply decreased the mutagenicity of a number of aryl- and heterocyclic amines, of aflatoxin B1, benzo[a]pyrene, 1,2-dibromoethane, and more selectively, of 2-nitropropane, all involving an induced rat liver S9 fraction. Good inhibition was found with 2 nitrosamines that required a hamster S9 fraction for biochemical activation. No effect was found with 1-nitropyrene, and with the direct-acting (no S9) 2-chloro-4-methyl-thiobutanoic acid. Thus, with some exceptions, polyphenols considerably decreased the mutagenicity of diverse types of carcinogens.

References

Sep 30, 1992·Cancer Letters·R W Teel, A Castonguay
Dec 15, 1991·Klinische Wochenschrift·M R Clemens
Jan 1, 1985·Pharmacology & Therapeutics·A DippleE K Weisburger
Jan 18, 1995·Journal of the National Cancer Institute·A TrichopoulouD Trichopoulos
Jun 1, 1994·Journal of the National Cancer Institute·Y T GaoJ F Fraumeni
Jul 7, 1993·Journal of the National Cancer Institute·C S Yang, Z Y Wang

❮ Previous
Next ❯

Citations

Mar 5, 2003·Teratogenesis, Carcinogenesis, and Mutagenesis·Yogeshwer ShuklaPankaj Taneja
Jan 6, 2000·Archives of Biochemistry and Biophysics·H ShihL C Quattrochi
Jan 1, 2003·Environmental Health and Preventive Medicine·John H Weisburger
Aug 30, 2008·Cancer Causes & Control : CCC·Yau-Chang KuoUNKNOWN Kaohsiung Leukemia Research Group
Feb 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Babli HalderAshok Kumar Giri
Nov 25, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E A VarandaW Vilegas
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T C HourJ K Lin
Jan 24, 2002·Cancer Letters·Yogeshwer Shukla, Pankaj Taneja
May 23, 2001·Nutrition·J H WeisburgerG Kuts-Cheraux
Jan 8, 1999·Mutation Research·Y Kuroda, Y Hara
Apr 29, 2009·Critical Reviews in Food Science and Nutrition·Vasundhara Sharma, L Jagan Mohan Rao
Sep 4, 2014·BMC Complementary and Alternative Medicine·Udayan BhattacharyaAshok K Giri
Nov 18, 2000·Mutation Research·J L MarnewickE Joubert
Mar 7, 2003·Mutagenesis·Fenton CatterallCostas Ioannides
Jun 1, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jihed BoubakerLeila Chekir-Ghedira
Oct 20, 2004·Mutation Research·Thiraviam GeethaIndu Pal Kaur
Nov 8, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Eliana Aparecida VarandaLourdes Campaner Dos Santos
Nov 1, 2005·Environmental Toxicology and Pharmacology·Soumaya KilaniLeila Chekir-Ghedira
Nov 13, 2015·Critical Reviews in Food Science and Nutrition·Brahma N SinghB R Singh
Apr 6, 1999·Japanese Journal of Cancer Research : Gann·N HamajimaK Okuma
Jul 22, 2008·Acta Cirúrgica Brasileira·Atila Varela VelhoCleber Dario Pinto Kruel
May 13, 2008·Brazilian Journal of Biology = Revista Brasleira De Biologia·L S AndradeL Chen-Chen
Nov 30, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Babli HalderAshok Kumar Giri
Nov 2, 2007·Environmental and Molecular Mutagenesis·Naíla Cannes do NascimentoJenifer Saffi
Jan 1, 2008·Nutrition Research and Practice·Jie YinMyeong-Hyeon Wang
Jan 21, 2006·Molecular Nutrition & Food Research·Imtiaz A SiddiquiHasan Mukhtar
Dec 29, 2013·Journal of Biomolecular Screening·Nicole A DoudicanSeth J Orlow
Oct 15, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Costas Ioannides, Victoria Yoxall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.