Teaching an old GABA receptor new tricks.

Anesthesia and Analgesia
James R TrudellM Bruce Maciver

Abstract

The accompanying articles in this issue of the journal's special collection describe attempts to improve on the dynamics of distribution and reduce side effects of analogs of etomidate and benzodiazepines. Both classes of drugs have their principal sites of action on γ-aminobutyric acid type A receptors, although at very different binding sites and by different mechanisms of action. Herein, we review the structure of γ-aminobutyric acid type A receptors and describe the location of the 2 likely binding sites. In addition, we describe how these drugs can interact with the nervous system at a systems level. We leave it to other reviewers to discuss whether these new drugs offer true clinical improvements.

References

Apr 1, 1993·Anesthesiology·D L TanelianM B MacIver
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·D BelelliP J Whiting
Jun 19, 2002·Trends in Biochemical Sciences·Brett A CromerMichael W Parker
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rachel JurdUwe Rudolph
Aug 30, 2005·Trends in Pharmacological Sciences·Hugh C HemmingsNeil L Harrison
Apr 7, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Victor Y ChengBeverley A Orser
Nov 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guo-Dong LiJonathan B Cohen
Dec 15, 2006·Nature·Nicolas BocquetPierre-Jean Corringer
Jan 26, 2011·Anesthesiology·Stuart A Forman
Jul 30, 2011·Nature Reviews. Drug Discovery·Uwe Rudolph, Frédéric Knoflach
Oct 4, 2011·Anesthesia and Analgesia·Ervin PejoDouglas E Raines
Nov 5, 2011·Anesthesia and Analgesia·Ri Le GeDouglas E Raines

❮ Previous
Next ❯

Citations

Sep 27, 2013·Hepatitis Monthly·Ali Dabbagh, Samira Rajaei
May 29, 2014·Trends in Pharmacological Sciences·James R TrudellR Adron Harris
Jul 1, 2014·Anesthesia and Analgesia·M Bruce MacIver
Nov 22, 2017·British Journal of Anaesthesia·J R Sneyd

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.