Teaching and practicing pharmacogenomics: a complex matter

Pharmacogenomics
J E Lunshof

Abstract

This opinion is a reply to the following article: Flordellis CS: The emergence of a new paradigm of pharmacogenomics. Pharmacogenomics 6(5), 515-526 (2005). Systems biology is likely to become a leading paradigm in molecular biology in coming decades. In pharmacogenomics, complexity is rapidly increasing as more genomics and proteomics data become available. Tackling this complexity by employing a systems approach seems to be a promising strategy. The introduction of this new paradigm will reshape both professional education and clinical practice. Professionals in medicine and the life sciences must be prepared to adapt to this new approach. However, systems-based pharmacogenomics is unlikely to be ready for clinical application in near future. In order to benefit patients today, the already available options of pharmacogenomics should be carefully implemented in clinical practice as soon as possible. Teaching the current, continuously updated knowledge of pharmacogenomics should not be postponed until the new paradigm arrives.

References

Aug 28, 2002·The Pharmacogenomics Journal·J Licinio, M-L Wong
Jan 10, 2003·Nucleic Acids Research·Gudmundur A Thorisson, Lincoln D Stein
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
May 2, 2003·Nature Biotechnology·Lourival D Possani
Dec 16, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Daniel W NebertElliot S Vesell
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Oct 8, 2004·Nature Biotechnology·Roger Brent
Oct 8, 2004·Nature Biotechnology·Leroy Hood, Roger M Perlmutter
Oct 8, 2004·Nature Biotechnology·Hans V Westerhoff, Bernhard O Palsson
Jul 15, 2005·Pharmacogenomics·Christodoulos S Flordellis
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Dec 24, 2005·Nature Reviews. Drug Discovery·David GurwitzRuss B Altman
Dec 23, 2006·Pharmacogenomics·Gary Hardiman

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Citations

Jan 21, 2012·Expert Reviews in Molecular Medicine·Aarti N Patel, Jack H Jhamandas
Jun 19, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stephan ZüchnerJean C Beckham
Dec 19, 2007·Pharmacogenomics·Yonghong Li, Andrew Grupe
Jul 4, 2008·Pharmacogenomics·Meenal GuptaRitushree Kukreti
Mar 25, 2008·Journal of the American Pharmacists Association : JAPhA·Shareen Y El-IbiaryBrian Alldredge
Jun 1, 2011·Molecular Diagnosis & Therapy·Nathalie K ZgheibRamzi Sabra

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Methods Mentioned

BETA
genotyping
pharmacotherapy

Software Mentioned

PGx

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