Teaching resource. Canonical Wnt/beta-catenin signaling

Science's STKE : Signal Transduction Knowledge Environment
Randall T Moon

Abstract

This animation provides an interactive presentation of the Wnt signaling pathway as it may occur in multiple cell types. This animation would be useful in teaching developmental biology, immunology, and cell signaling courses. Activation of Wnt pathways can modulate cell proliferation, cell survival, cell behavior, and cell fate. In the basal, unstimulated state in the absence of ligand, there is a constitutively active kinase, which phosphorylates target proteins, resulting in their degradation. Thus, the presence of the ligand Wnt inactivates the kinase allowing accumulation of beta-catenin, which then translocates to the nucleus and acts as a transcriptional regulator.

Citations

Dec 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Masao SaotomeGyörgy Hajnóczky
Jan 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hwei-Jan Hsu, Daniela Drummond-Barbosa
Nov 3, 2015·Biochimica Et Biophysica Acta·Mohammed S Razzaque, Azeddine Atfi
Nov 10, 2017·Frontiers in Cell and Developmental Biology·Gurjoth S J DeolGregory M Kelly
Oct 28, 2005·Nature·Dieter-Chichung LieFred H Gage
Sep 7, 2017·Genesis : the Journal of Genetics and Development·Jolanda J D de RooFrank J T Staal
Jan 31, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiao-Juan WangLi You
Feb 8, 2005·Molecular Endocrinology·Izhar Ben-Shlomo, Aaron J W Hsueh
Oct 10, 2013·Cancer Prevention Research·Sung-Young LeeZigang Dong

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