Tear and serum vitamin D levels in children with allergic rhinoconjunctivitis

Allergologia et immunopathologia
Sevil Bilir GoksugurFatih Demircioglu

Abstract

Although solid cohort studies confirmed a preventative role for the anti-oxidant vitamin D in allergic asthma, a limited number of studies focused on allergic rhinoconjunctivitis (ARC). Here, we aimed to determine 25-hydroxycholecalciferol levels in tear and serum in young allergic rhinoconjunctivitis patients as compared to their apparently healthy matched controls. In total, 22 children with allergic rhinoconjunctivitis and 31 healthy control subjects underwent serum total IgE and 25-hydroxycholecalciferol measurements. Tear levels of 25-hydroxycholecalciferol were also determined in both groups. The mean serum total IgE level in the ARC group (143.6±132.8IU/ml) was significantly higher than that in the control group (54.8±44.1IU/ml; p=0.03). Serum 25(OH)D levels were significantly higher in the ARC group (34.1±12.7ng/ml) than in the healthy controls (21.8±11.3ng/ml; p=0.001). To our knowledge, this is the first reported study to show an association between serum 25-hydroxycholecalciferol and ARC in a childhood group. Higher levels of serum 25-hydroxycholecalciferol in children with allergic rhinoconjunctivitis may indicate a possible aetiopathogenic mechanism in the development of allergic rhinoconjunctivitis. This is also t...Continue Reading

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Citations

Jan 10, 2016·International Journal of Pediatric Otorhinolaryngology·Mahmut Dogru, Ayse Suleyman
Jul 28, 2016·Maternal & Child Nutrition·C T CairncrossP R von Hurst
Feb 6, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Z-Q LiuP-C Yang
Jan 8, 2020·BMC Ophthalmology·Min-Chul ChoSeong-Jae Kim
Sep 7, 2016·Eye and Vision·Swaminathan SethuArkasubhra Ghosh
May 16, 2019·Ear, Nose, & Throat Journal·Khaled SaadAmira Elhoufey
Dec 15, 2020·European Journal of Ophthalmology·Rana SorkhabiSasan Jafari
Feb 4, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nurgül ÖrnekÜçler Kısa

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