Tear film and ocular surface dysfunction in diabetes mellitus in an Indian population

Indian Journal of Ophthalmology
Divya KesarwaniZiya Siddiqui

Abstract

Ophthalmic complications in diabetes such as retinopathy, cataract, and infections have been extensively studied. Recently, attention has been drawn toward ocular surface changes in diabetes mellitus (DM). This study has been carried out to investigate the tear film and ocular surface abnormalities in type II DM patients. A total of 83 participants (130 eyes) were enrolled: 53 diabetics (80 eyes) and 30 healthy controls (50 eyes). Of the 53 diabetics, 24 patients (42 eyes) had some diabetic retinopathy. The tear film and ocular surface were evaluated using Schirmer test, tear film break-up time (TBUT), keratoepitheliopathy score (KES), Rose Bengal Staining (RBS) test, and conjunctival impression cytology. When compared with the healthy controls, diabetics showed significantly reduced Schirmer, TBUT measurements and the higher grades of KES and RBS test (P < 0.001). Impression cytology analysis showed goblet cell loss and conjunctival squamous metaplasia in diabetics. Tear film abnormality is a significant feature of diabetic ocular surface diseases. These abnormalities are likely on account of poor quality and function of tears, combined with the subnormal ocular surface. Therefore, all diabetic patients especially those with e...Continue Reading

References

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Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

Jul 6, 2020·Clinical and Experimental Pharmacology & Physiology·Thekkuttuparambil A Ajith
Apr 1, 2021·Ophthalmology·Kimberley YuUNKNOWN Dry Eye Assessment and Management Study Research Group

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