Tear film concentrations of topically applied 0.5% oxytetracycline ointment in normal canine eyes.

Veterinary Ophthalmology
Alex B SigmundDiane V H Hendrix

Abstract

To determine the tear film levels of oxytetracycline in normal canine eyes after application of the ophthalmic ointment, Terramycin™ (0.5% oxytetracycline, polymyxin B sulfate), to guide appropriate treatment frequency. Ten research beagles. Ten research beagles with confirmed normal eyes were administered 0.02 mL of Terramycin™ ophthalmic ointment onto the dorsal bulbar conjunctival surface of the right eye. Tear samples were collected via dye-less Schirmer tear strips at 2, 4, 6, 8, and 12 hours post-administration. The sample for each timepoint was collected on a separate day, and concentrations of oxytetracycline were determined using high-performance liquid chromatography (HPLC). There was a semi-logarithmic decline in the median tear concentration of oxytetracycline. The median (2.5th and 97.5th percentiles) tear concentrations of oxytetracycline at 2, 4, 6, 8, and 12 hours were 43.5 μg/mL (11.1-302.2 μg/mL), 28.7 μg/mL (8.04-113.7 μg/mL), 16.1 μg/mL (4.96-37.7 μg/mL), 9.2 μg/mL (4.52-28.1 μg/mL), and 6.11 μg/mL (4.36-26.7 μg/mL), respectively. Mean (±SD) drug recovery via HPLC was 88% (±7.5%). Ophthalmic Terramycin™ achieves a substantially higher tear level than the MIC for common bacterial corneal pathogens up to 12 ho...Continue Reading

References

Jan 1, 1989·Journal of Pharmaceutical and Biomedical Analysis·H FabreB Mandrou
Mar 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·L W GeorgeR Kaswan
Jan 1, 1982·Survey of Ophthalmology·J W Shell
Nov 1, 1994·Cornea·M Limberg, C Buggé
Jan 1, 1994·European Journal of Pharmacology·S GrimwoodA C Foster
Apr 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·M A BallW S Schwark
Feb 11, 1999·Advances in Dental Research·M L Nelson
Apr 28, 2004·The Veterinary Clinics of North America. Small Animal Practice·Dennis E Brooks, Franck J Ollivier
Jan 24, 2006·Journal of the American Veterinary Medical Association·Erica L TolarKirk N Gelatt
Jan 31, 2006·Journal of the American Academy of Dermatology·Allen N Sapadin, Raul Fleischmajer
Jun 15, 2007·Veterinary Ophthalmology·F J OllivierD E Brooks
Nov 1, 2007·Veterinary Ophthalmology·Diane V H HendrixSherry K Cox
Jan 15, 2008·Veterinary Ophthalmology·Diane V H Hendrix, Sherry K Cox
Mar 1, 2008·Journal of Veterinary Pharmacology and Therapeutics·A HartmannK Hartmann
Dec 3, 2008·Veterinary Ophthalmology·Amy BakerDennis E Brooks
Apr 8, 2009·Antimicrobial Agents and Chemotherapy·Geoffrey A McKayGregory Moeck
Jan 5, 2011·Veterinary Ophthalmology·Medhat W ShafaaGhada G El hossary
May 15, 2013·Burns : Journal of the International Society for Burn Injuries·N KapalschinskiT Hirsch
Oct 14, 2014·Current Eye Research·Gaoqin LiuPeirong Lu
Aug 25, 2016·Journal of the American Veterinary Medical Association·Sean P CollinsRalph E Hamor
May 1, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lionel SebbagJonathan P Mochel
Oct 17, 2018·Pharmaceutical Research·Quanying Bao, Diane J Burgess
Aug 6, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lionel SebbagJonathan P Mochel
Jan 11, 2020·Frontiers in Veterinary Science·Lionel SebbagJonathan P Mochel
Feb 13, 2020·Frontiers in Pharmacology·Lionel SebbagJonathan P Mochel

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Veterinary Medical Association
E M SmithT B Farver
Journal of the American Pharmaceutical Association
The Practitioner
T ANDERSON
© 2022 Meta ULC. All rights reserved