Tear Metabolomics in Dry Eye Disease: A Review

International Journal of Molecular Sciences
Mazyar YazdaniTor Paaske Utheim

Abstract

Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear film. It is considered one of the most common ocular conditions leading patients to seek eye care. The current method for diagnostic evaluations and follow-up examinations of DED is a combination of clinical signs and symptoms determined by clinical tests and questionnaires, respectively. The application of powerful omics technologies has opened new avenues toward analysis of subjects in health and disease. Metabolomics is a new emerging and complementary research discipline to all modern omics in the comprehensive analysis of biological systems. The identification of distinct metabolites and integrated metabolic profiles in patients can potentially inform clinicians at an early stage or during monitoring of disease progression, enhancing diagnosis, prognosis, and the choice of therapy. In ophthalmology, metabolomics has gained considerable attention over the past decade but very limited such studies have been reported on DED. This paper aims to review the application of tear metabolomics in DED.

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Citations

Jul 22, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Neshe Nazifova-TasinovaChristina Grupcheva
Jan 5, 2021·Journal of Toxicology and Environmental Health. Part a·Jung Dae LeeKyu-Bong Kim
Feb 5, 2021·International Journal of Pharmaceutics·Suppakan Sripetch, Thorsteinn Loftsson
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Oct 16, 2020·Cornea·Takenori InomataAkira Murakami
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Laura E DownieJames S Wolffsohn
Jun 5, 2021·Journal of Occupational Health·Fatemeh EstarkiJamileh Abolghasemi
Aug 10, 2021·Current Eye Research·Mazyar YazdaniTor Paaske Utheim
Aug 25, 2021·The American Journal of Pathology·Xinwei JiaoZhijie Li

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Methods Mentioned

BETA
imaging techniques
nuclear magnetic resonance
electrophoresis
NMR

Software Mentioned

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