PMID: 15223813Jun 30, 2004Paper

Tear secretion induced by selective stimulation of corneal and conjunctival sensory nerve fibers

Investigative Ophthalmology & Visual Science
M Carmen AcostaJuana Gallar

Abstract

To measure the increase in tear secretion evoked by selective stimulation of the different populations of sensory receptors of the cornea and conjunctiva by using moderate and intense mechanical, chemical, and cold stimuli. Six healthy subjects participated in the study. Tear secretion was measured in both eyes by the Schirmer's test conducted under control conditions and after stimulation of the center of the cornea and the temporal conjunctiva with a gas esthesiometer. Mechanical stimulation consisted in three pulses of 3 seconds' duration of warmed air (at 34 degrees C on the eye surface) applied at moderate (170 mL/min) and high (260 mL/min) flow rates. Cold thermal stimulation was made with cooled air that produced a corneal temperature drop of -1 degrees C or -4.5 degrees C. Chemical (acidic) stimulation was performed with a jet of gas containing a mixture of 80% CO(2) in air. The basal volume of tear secretion increased significantly (P < 0.05, paired t-test) after stimulation of the cornea with high-flow mechanical stimuli (260 mL/min), intense cooling pulses (-4.5 degrees C), and chemical stimulation (80% CO(2)). The same stimuli were ineffective when applied to the conjunctiva. Moderate mechanical (170 mL/min) and col...Continue Reading

Citations

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