Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development

Gene Expression Patterns : GEP
Isabelle ManfroidL Fasano

Abstract

Drosophila teashirt (tsh) is involved in the patterning of the trunk identity together with the Hox genes. In addition, it is also a player in the Wingless and the Hedgehog pathways. In birds and mammals, three Tshz genes are identified and the expression patterns for mouse Tshz1 and Tshz2 have been reported during embryogenesis. Recently, we showed that all three mouse Tshz genes can rescue the Drosophila tsh loss-of-function phenotype, indicating that the function of the teashirt genes has been conserved during evolution. Here we describe the expression pattern of chick TSHZ3 during embryogenesis. Chick TSHZ3 is expressed in several tissues including mesodermal derivatives, the central and peripheral nervous systems. Emphasis is laid on the dynamic expression occurring in regions of the somites and limbs where tendons develop. We show that TSHZ3 is activated in the somites by FGF8, a known inducer of the tendon marker SCX.

References

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Citations

Aug 23, 2008·Disability and Rehabilitation·Richard BulloughNicholas R Forsyth
Nov 17, 2009·Gene Expression Patterns : GEP·Christian N PaxtonGary C Schoenwolf
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Neal AnthwalAbigail S Tucker
Jun 30, 2011·Genesis : the Journal of Genetics and Development·Timothy EricksonAndrew J Waskiewicz
Jan 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Joana S SantosFernando Casares

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