teashirt is required for head-versus-tail regeneration polarity in planarians

Development
Jared H OwenPeter W Reddien

Abstract

Regeneration requires that the identities of new cells are properly specified to replace missing tissues. The Wnt signaling pathway serves a central role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc-finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals and at posterior-facing wounds. Inhibition of Smed-teashirt (teashirt) by RNA interference (RNAi) resulted in the regeneration of heads in place of tails, a phenotype previously observed with RNAi of the Wnt pathway genes β-catenin-1, wnt1, Dvl-1/2 or wntless. teashirt was required for β-catenin-1-dependent activation of posterior genes during regeneration. These findings identify teashirt as a transcriptional target of Wnt signaling required for Wnt-mediated specification of posterior blastemas.

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Citations

Apr 12, 2016·ELife·M Lucila ScimonePeter W Reddien
Sep 9, 2016·Regeneration·Suthira Owlarn, Kerstin Bartscherer
Oct 11, 2016·Current Opinion in Cell Biology·Steffen WernerJochen C Rink
Jan 14, 2020·Current Biology : CB·Erik G Schad, Christian P Petersen
Mar 30, 2021·PLoS Genetics·Jennifer K CloutierPeter W Reddien

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