PMID: 9420726Sep 1, 1994Paper

Technetium 94m-labeled methoxyisobutyl isonitrile: dosimetry and resting cardiac imaging with positron emission tomography

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
C K StoneS B Perlman

Abstract

Development of a positron-emitting form of technetium has allowed the imaging of technetium radiopharmaceuticals with positron emission tomography (PET). We used 94mTc to compare the distribution of the myocardial perfusion agent sestamibi at rest with the conventional PET perfusion tracer 13N-labeled ammonia (13N-ammonia). Dosimetry calculations were performed with the known whole-body distribution of 99mTc-labeled sestamibi. Dynamic PET imaging of 13N-ammonia and 94mTc-labeled sestamibi (94mTc-sestamibi) for 32 minutes was performed in eight patients with previous myocardial infarction. Initial myocardial and extramyocardial distribution of 94mTc-sestamibi was compared with that of 13N-ammonia by qualitative and quantitative analysis. Quantitative comparison of the two tracers was performed with region-of-interest analysis and circumferential profiles. Qualitatively, the cardiac distribution of the tracers was similar in normal and infarcted myocardium. A decrease in the definition of the epicardial and endocardial borders of the heart was seen with 94mTc-sestamibi, presumably because of the lower dose of radionuclide injected. Quantitatively, there was no difference in infarct size, defined prospectively as tracer activity l...Continue Reading

References

Oct 16, 1990·The American Journal of Cardiology·E V GarciaN Ezquerra
Apr 3, 1986·The New England Journal of Medicine·J TillischH Schelbert
Jan 1, 1985·Journal of the American College of Cardiology·A ShahS C Huang
Jan 1, 1994·Journal of the American College of Cardiology·S G SawadaM Schwaiger

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Citations

Jul 1, 1996·European Journal of Nuclear Medicine·G Hör
Jul 3, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Abass Alavi, Sandip Basu
Aug 12, 2000·Nuclear Medicine and Biology·S M Qaim
Jan 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R J Burns
Mar 21, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·N P SandM Rehling
May 20, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A J Sinusas
Nov 17, 2001·Seminars in Nuclear Medicine·R C Mease, C Lambert
Oct 19, 2006·Nuclear Medicine and Biology·Heather M BigottMichael J Welch
Sep 10, 2020·Nuclear Medicine and Biology·Heinz H Coenen, Johannes Ermert

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