Abstract
Amiodarone (AD)-induced pulmonary toxicity is one of the major complications of long-term AD therapy. Technetium-99m-labeled D: ,L: -hexamethylpropylene amine oxime (Tc-99m HMPAO) scintigraphy has been used to assess lung injury. We designed this study to clarify lung uptake changes of Tc-99m HMPAO using low doses of AD (5 mg/kg/day) during long-term therapy in a rabbit model. Group 1 consisted of 7 rabbits fed with AD by gavage for 6 months. To investigate the effect of ketamine on Tc-99m HMPAO uptake, 5 rabbits were included in Group 2 as a control group. Tc-99m HMPAO scintigraphy was performed in both Group 1 and Group 2 at baseline and after 2, 4, 6, 8, and 12 weeks of AD intake. After 16, 20, and 24 weeks of drug intake, Tc-99m HMPAO scintigraphy was repeated only in group 1. One-min anterior images were acquired 30 min after the injection of 37 MBq of Tc-99m HMPAO. For semiquantitative evaluation, the mean count values were obtained and lung/background and liver/background ratios were calculated. Histopathologic evaluation was performed. No increase in lung and liver uptake of Tc-99m HMPAO was found 2, 4, 6, 8, and 12 weeks after drug intake. There was no significant increase in L/B and H/B ratios of Tc-99m HMPAO in Group...Continue Reading
References
May 1, 1992·Thorax·J RocaG Sanz
Aug 1, 1992·Annals of Internal Medicine·S G KimJ D Fisher
Aug 1, 1992·American Heart Journal·J SummittA Kadish
Jan 1, 1992·Journal of the American College of Cardiology·S J EvansW Mandel
Sep 1, 1991·Clinical Nuclear Medicine·W J ShihU Y Ryo
Jun 1, 1988·Chest·Y Y ZhuM Scheinman
Sep 1, 1980·American Heart Journal·H H RotmenschS Laniado
Nov 15, 1993·Journal of the American College of Cardiology·S J KalbfleischF Morady
Mar 1, 1993·Clinical Nuclear Medicine·W J ShihM L Dillon
Oct 1, 1996·Chest·J Hilbert, V Mohsenin
Jul 1, 1997·Respiratory Medicine·B GunaydinS Yardim
Sep 19, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S E RossiP C Goodman
Apr 24, 2001·European Journal of Nuclear Medicine·G Capa KayaH Durak
Nov 3, 2001·Journal of Hepatology·M SpaniolS Krähenbühl
Jan 2, 2003·Annals of Nuclear Medicine·Aysegul DirlikZeynep Burak
Jun 7, 2003·Annals of Nuclear Medicine·Hatice DurakBanu Sis
Jul 25, 2003·Lung·C-J HungC-C Lee
Sep 4, 2003·Lung·C-H ChangA Kao
Apr 6, 2004·Clinics in Chest Medicine·Philippe CamusEdward C Rosenow
Jun 15, 2004·International Journal of Cardiology·Gulay Durmus-AltunGulay Ozbay
Citations
Apr 6, 2013·Annals of Nuclear Medicine·G GumuserE Sayit
Jun 24, 2008·Lab Animal·Gary Martinic
May 26, 2012·Journal of Applied Physiology·Said H AudiAnne V Clough
Jan 6, 2021·Journal of Clinical Medicine·Irma Mahmutovic Persson On Behalf Of The Tristan Consortium
Oct 23, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Anne V CloughDavid L Roerig