Technetium-99m hexamethylpropylene amine oxime lung scintigraphy findings in low-dose amiodarone therapy.

Lung
G Capa KayaH Durak

Abstract

Amiodarone (AD)-induced pulmonary toxicity is one of the major complications of long-term AD therapy. Technetium-99m-labeled D: ,L: -hexamethylpropylene amine oxime (Tc-99m HMPAO) scintigraphy has been used to assess lung injury. We designed this study to clarify lung uptake changes of Tc-99m HMPAO using low doses of AD (5 mg/kg/day) during long-term therapy in a rabbit model. Group 1 consisted of 7 rabbits fed with AD by gavage for 6 months. To investigate the effect of ketamine on Tc-99m HMPAO uptake, 5 rabbits were included in Group 2 as a control group. Tc-99m HMPAO scintigraphy was performed in both Group 1 and Group 2 at baseline and after 2, 4, 6, 8, and 12 weeks of AD intake. After 16, 20, and 24 weeks of drug intake, Tc-99m HMPAO scintigraphy was repeated only in group 1. One-min anterior images were acquired 30 min after the injection of 37 MBq of Tc-99m HMPAO. For semiquantitative evaluation, the mean count values were obtained and lung/background and liver/background ratios were calculated. Histopathologic evaluation was performed. No increase in lung and liver uptake of Tc-99m HMPAO was found 2, 4, 6, 8, and 12 weeks after drug intake. There was no significant increase in L/B and H/B ratios of Tc-99m HMPAO in Group...Continue Reading

References

Aug 1, 1992·Annals of Internal Medicine·S G KimJ D Fisher
Jan 1, 1992·Journal of the American College of Cardiology·S J EvansW Mandel
Sep 1, 1991·Clinical Nuclear Medicine·W J ShihU Y Ryo
Sep 1, 1980·American Heart Journal·H H RotmenschS Laniado
Mar 1, 1993·Clinical Nuclear Medicine·W J ShihM L Dillon
Sep 19, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S E RossiP C Goodman
Apr 24, 2001·European Journal of Nuclear Medicine·G Capa KayaH Durak
Nov 3, 2001·Journal of Hepatology·M SpaniolS Krähenbühl
Jun 7, 2003·Annals of Nuclear Medicine·Hatice DurakBanu Sis
Apr 6, 2004·Clinics in Chest Medicine·Philippe CamusEdward C Rosenow

❮ Previous
Next ❯

Citations

Jan 6, 2021·Journal of Clinical Medicine·Irma Mahmutovic Persson On Behalf Of The Tristan Consortium
Oct 23, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Anne V CloughDavid L Roerig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.