PMID: 11345176May 10, 2001Paper

Technetium-99m HMPAO-labeled leukocyte imaging compared with endoscopy, ultrasonography, and contrast radiology in children with inflammatory bowel disease

Journal of Pediatric Gastroenterology and Nutrition
J L AlberiniT Dupont

Abstract

The purpose of this study was to evaluate retrospectively the value of leukocyte-labeled scintigraphy, ultrasonography, and contrast radiography compared with endoscopy in children suspected of having inflammatory bowel disease (IBD). Twenty-eight children (17 boys; mean age, 10.2 years) with IBD based on standard colonoscopic, histologic, and radiologic criteria (16 with Crohn's disease, 5 with ulcerative colitis, 5 with nonspecific colitis, I with granulomatous disease, and I with Beh,cet's disease) were included. Endoscopic, ultrasonographic, and contrast radiologic examinations were realized for 28, 23, and 19 children respectively. Sensitivity and specificity were 75% and 92% for leukocyte-labeled scintigraphy, 39% and 90% for ultrasonography, and 58% and 83% for contrast radiography. The authors noted discontinuous uptake for 14 of 15 true-positive results for patients with Crohn's disease and continuous uptake for 4 of 4 true-positive results for patients with ulcerative colitis. A negative correlation between scan activity index and Lloyd-Still clinical score was found for 11 patients with Crohn's disease (r = -0.77). Leukocyte-labeled scintigraphy, a noninvasive and reproducible technique, is a useful tool in the diagn...Continue Reading

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Citations

Jul 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·UNKNOWN IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition
Jun 13, 2009·World Journal of Gastroenterology : WJG·Maria I StathakiIoannis E Koutroubakis
May 21, 2014·Gastroenterology Report·Parakkal Deepak, David H Bruining
Jul 30, 2010·European Journal of Pediatrics·Federico CaobelliRaffaele Giubbini
Jun 5, 2007·Seminars in Nuclear Medicine·James Claude Warrington, Martin Charron
Feb 23, 2010·Journal of Cellular Physiology·Andor W J M GlaudemansAlberto Signore
Jun 11, 2014·Best Practice & Research. Clinical Gastroenterology·F DambhaN Carroll
Feb 9, 2012·Gastroenterology Research and Practice·Gianluca GattaRoberto Grassi
Nov 16, 2016·World Journal of Radiology·Federico Caobelli Young Aimn Working Group
Jun 9, 2005·Nuclear Medicine Communications·Alessio AnnovazziAlberto Signore
Nov 27, 2010·Expert Review of Gastroenterology & Hepatology·Gianluca BeneventoDario Sorrentino
Nov 27, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Erik H J G AarntzenWim J G Oyen

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