PMID: 9420803Jul 1, 1995Paper

Technetium 99m-labeled sestamibi imaging reliably identifies retained contractile reserve in dyssynergic myocardial segments

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
R SeniorA Lahiri

Abstract

Recently there has been considerable controversy regarding the use of 99mTc-labeled sestamibi as an agent for the detection of viable myocardium. In this study we have used dobutamine-induced left ventricular wall thickening by echocardiography in regions with evidence of resting dyssynergy of the left ventricle as an indicator of retained contractile reserve and compared this with 99m Tc-labeled sestamibi uptake in the same regions. Twenty-seven patients with documented coronary artery disease and severe regional wall motion abnormalities underwent low-dose (5 to 15 micrograms/kg/min) dobutamine echocardiography and maximal (15 to 40 micrograms/kg/min) stress dobutamine 99mTc-labeled sestamibi single-photon emission computed tomographic imaging. Separate-day rest 99mTc-labeled sestamibi scanning was also performed. 99mTc-labeled sestamibi uptake was assessed semiquantitatively from grades from 1 to 4, from normal to absent perfusion. Regions with grade 3 or less uptake were considered viable by 99mTc-labeled sestamibi. Of the 34 regions with severe wall motion abnormalities by echocardiography, 32 showed improved wall thickening with low-dose dobutamine. Rest 99mTc-labeled sestamibi detected retained myocardial viability in 29...Continue Reading

References

Mar 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·B SridharaA Lahiri

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Citations

Aug 29, 2006·Heart Failure Reviews·Roxy Senior
Jun 19, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kevin C Allman
Dec 14, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Paramjit JeetleyAvijit Lahiri
Apr 4, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Antonio MicariJonathan R Lindner

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