Technetium Tc 99m rapidly crosses the ovine placenta and intramembranous pathway

American Journal of Obstetrics and Gynecology
W M GilbertR A Brace

Abstract

This study examined the movement of the soluble ion technetium Tc 99m across the ovine placenta and intramembranous pathway. Nineteen fetal sheep at 131 +/- 1 (SE) days' gestation were studied. After a 1-hour control period technetium Tc 99m was injected into either a fetal vein (n = 7), the amniotic cavity (n = 5), or a maternal vein (n = 5). Maternal and fetal blood, fetal urine, and amniotic and allantoic fluid were sampled during the control period and for 8 hours after the injection. Fetal urine was drained externally throughout the experiment. In five animals technetium Tc 99m was injected intraamniotically after the fetus was killed with air emboli and sampled as described. Intrafetally injected technetium Tc 99m rapidly crossed the placenta; then it entered and was concentrated in the amniotic cavity. Intraamniotically injected technetium Tc 99m rapidly entered into the fetal circulation. The maternally injected technetium Tc 99m rapidly crossed the placenta into the fetus, suggesting a half-time for placental exchange of < 50 minutes. The technetium Tc 99m injected into the dead fetus group demonstrated significantly less maternal absorption than in the live fetus group. The soluble ion technetium Tc 99m demonstrated a...Continue Reading

References

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Citations

Oct 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jen-Ruey TangSteven H Abman
May 16, 2009·Reproductive Toxicology·Christof SchaeferCorinna Weber-Schoendorfer
Nov 1, 2015·British Journal of Clinical Pharmacology·Maïlys De Sousa MendesSihem Benaboud
May 17, 2002·American Journal of Obstetrics and Gynecology·Robert GagnonRobert A Brace
Oct 7, 2004·American Journal of Obstetrics and Gynecology·Robert A BraceEvelien Huijssoon
Dec 14, 2004·American Journal of Obstetrics and Gynecology·Shengbiao WangMichael G Ross
Dec 11, 2008·Neonatal Network : NN·Patti Schurr, Esther M Perkins
Apr 30, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Mark A UnderwoodMichael P Sherman
Apr 28, 2006·Journal of the Society for Gynecologic Investigation·Shengbiao WangMichael G Ross
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Soham DasguptaSunil K Jain
Dec 22, 2017·Journal of the Endocrine Society·Mishaela R Rubin, Shonni J Silverberg
May 9, 2019·Journal of the Endocrine Society·Aimee Natasha DiMarcoFrancesco Fausto Palazzo
Oct 21, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marianne GarlandRaymond I Stark
May 1, 2021·Biomedicines·Elena Tsourdi, Athanasios D Anastasilakis

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