PMID: 6981107Jul 1, 1981Paper

Technical and theoretical considerations in the HLA typing of amniotic fluid cells for prenatal diagnosis and paternity testing

Prenatal Diagnosis
M S PollackG J O'Neill

Abstract

HLA typing of amniotic fluid cells has been used for the prenatal diagnosis of the HLA linked diseases congenital adrenal hyperplasia (21-OH-deficiency (21-OH-def) type) and complement C4 deficiency and it has also been used for the prenatal determination of paternity. There are, however, technical difficulties in this test associated with the weak expression of some B locus antigens on amniotic fluid cells, and theoretical difficulties related to associations between particular HLA antigens and the 21-OH-def allele. Since certain HLA-B locus antigens are found in significantly increased frequencies among patients with 21-OH-def, there is a relatively high incidence of HLA-B homozygosity among the patients and over 40 per cent of the parents of these patients share one or more HLA-B locus antigens. Results of some prenatal HLA typing tests may thus be difficult to interpret, and supplementary tests should be used whenever possible. HLA typing of amniotic cells is, however, the only available procedure for prenatal diagnosis of C4 deficiency and it is the best available procedure for prenatal determination of paternity. A modification of our original procedure allows HLA typing to be performed with increased numbers of HLA typin...Continue Reading

References

May 26, 1978·Science·G S Omenn
Jul 26, 1979·The New England Journal of Medicine·C BeaumontM Bourel
Jul 26, 1979·The New England Journal of Medicine·G E CartwrightL Buskjaer
Feb 23, 1978·Human Genetics·P CouillinA Boué
Jan 1, 1978·Human Heredity·L P RyderA Svejgaard
Oct 26, 1978·The New England Journal of Medicine·L S LevineB Dupont
Jan 1, 1974·Tissue Antigens·P L MattiuzM Massobrio
Sep 1, 1980·Clinical Genetics·P D BuchananW L Nyhan

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Citations

Jul 1, 1987·The Journal of Pediatrics·W L Miller, L S Levine
Sep 10, 2005·American Journal of Obstetrics and Gynecology·Stephen G M CarrollPhillipa Mm Kyle
Oct 1, 1982·Prenatal Diagnosis·D F Roberts, D V Coleman
Dec 1, 1983·American Journal of Medical Genetics·J J NoraJ Walknowska
Apr 1, 1982·Prenatal Diagnosis·M Adinolfi
Feb 1, 1983·Tissue Antigens·E Valentine-ThonE Passarge

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