Technical Note: A Monte Carlo study of magnetic-field-induced radiation dose effects in mice

Medical Physics
Ashley E RubinsteinLaurence E Court

Abstract

Magnetic fields are known to alter radiation dose deposition. Before patients receive treatment using an MRI-linear accelerator (MRI-Linac), preclinical studies are needed to understand the biological consequences of magnetic-field-induced dose effects. In the present study, the authors sought to identify a beam energy and magnetic field strength combination suitable for preclinical murine experiments. Magnetic field dose effects were simulated in a mouse lung phantom using various beam energies (225 kVp, 350 kVp, 662 keV [Cs-137], 2 MV, and 1.25 MeV [Co-60]) and magnetic field strengths (0.75, 1.5, and 3 T). The resulting dose distributions were compared with those in a simulated human lung phantom irradiated with a 6 or 8 MV beam and orthogonal 1.5 T magnetic field. In the human lung phantom, the authors observed a dose increase of 45% and 54% at the soft-tissue-to-lung interface and a dose decrease of 41% and 48% at the lung-to-soft-tissue interface for the 6 and 8 MV beams, respectively. In the mouse simulations, the magnetic fields had no measurable effect on the 225 or 350 kVp dose distribution. The dose increases with the Cs-137 beam for the 0.75, 1.5, and 3 T magnetic fields were 9%, 29%, and 42%, respectively. The dose...Continue Reading

References

Mar 1, 1977·Medical Physics·D P WhitmireJ A Purdy
Aug 13, 2002·Physics in Medicine and Biology·James L RobarM A Martin
Apr 28, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·George RodriguesJake Van Dyk
Oct 9, 2004·Physics in Medicine and Biology·B W RaaymakersJ J W Lagendijk
Aug 16, 2005·Academic Radiology·Arundhuti GangulyRebecca Fahrig
Aug 1, 2007·Physics in Medicine and Biology·A J E RaaijmakersJ J W Lagendijk
Feb 12, 2008·Physics in Medicine and Biology·A J E RaaijmakersJ J W Lagendijk
Apr 15, 2008·Medical Physics·C KirkbyB G Fallone
May 20, 2009·Physics in Medicine and Biology·B W RaaymakersK J Brown
Sep 3, 2009·Physics in Medicine and Biology·G PoludniowskiF Verhaegen
Jul 23, 2011·Medical Physics·Sarah B ScarboroStephen F Kry
Jun 17, 2014·Seminars in Radiation Oncology·Sasa Mutic, James F Dempsey
Jun 17, 2014·Seminars in Radiation Oncology·Jan J W LagendijkMarco van Vulpen
Mar 10, 2015·Physics in Medicine and Biology·Charis KontaxisB W Raaymakers
Jun 25, 2015·International Journal of Radiation Oncology, Biology, Physics·H Omar WootenSasa Mutic

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Citations

Oct 26, 2018·The British Journal of Radiology·Jonathan Kim MohajerGiuseppe Schettino
Jun 30, 2019·Journal of Applied Clinical Medical Physics·Xinfeng ChenX Allen Li
Nov 18, 2018·PloS One·Ashley E RubinsteinLaurence E Court
Nov 20, 2019·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Takahiro KubotaTakeshi Ohno

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