Technical Note: Efficient and accurate MRI-only based treatment planning of the prostate using bulk density assignment through atlas-based segmentation

Medical Physics
Hazel M McCallumStina Svensson

Abstract

This study investigates the dosimetric accuracy as well as the robustness of a bulk density assignment approach to magnetic resonance imaging (MRI)-only based treatment planning of the prostate, with bulk density regions automatically identified using atlas-based segmentation (ABS). Twenty prostate radiotherapy patients received planning computed tomography (CT) and MRI scans and were treated with volumetric modulated arc therapy (VMAT). Two bulk densities were set, one for bone and one for soft tissue. The bone contours were created by using ABS followed by manual modification if considered necessary. A range of soft tissue and bone density pairs, between 0.95 and 1.03 g/cm3 with increments of 0.01 for soft tissue, and between 1.15 and 1.65 g/cm3 with increments of 0.05 for bone, were evaluated. Using the density pair giving the lowest dose difference compared to the CT-based dose, dose differences were calculated using both the manually modified bone contours and the bone contours from ABS. Contour overlap measurements between the ABS contours and the manually modified contours were calculated. The dose comparison shows a very good agreement with the CT when using 0.98 g/cm3 for soft tissue and 1.20 g/cm3 for bone, with a dos...Continue Reading

References

Aug 6, 1998·The British Journal of Radiology·A W BeavisV J Whitton
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Lili ChenAlan Pollack
Jul 30, 2008·Acta Oncologica·Karsten EilertsenArne Skretting
Jul 30, 2010·IEEE Transactions on Medical Imaging·Thomas Robin LangerakJosien P W Pluim
Feb 23, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jonathan LambertOlivier Salvado
Nov 18, 2011·Journal of Applied Clinical Medical Physics·Aliaksandr KarotkiMichael Meltsner
Jan 11, 2014·Radiation Oncology·Marie E KorsholmJens M Edmund
Jan 8, 2015·Medical Physics·Ola Weistrand, Stina Svensson
Aug 13, 2015·BMC Medical Imaging·Abdel Aziz Taha, Allan Hanbury
Dec 20, 2017·International Journal of Radiation Oncology, Biology, Physics·Emily JohnstoneRichard Speight
Aug 16, 2018·International Journal of Radiation Oncology, Biology, Physics·Anna M DinklaCornelis A T van den Berg
Aug 16, 2018·Physics in Medicine and Biology·Matteo MasperoCornelis A T van den Berg
Dec 5, 2019·Physics and Imaging in Radiation Oncology·Jonathan J WyattHazel M McCallum

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.